* current need for hospitalization or anticipated need for hospitalization within 24 h after randomization * known medical history of active liver disease * known hiv infection with a viral load \>400 copies/ml or taking prohibited medications for human immunodeficiency virus (hiv) * receiving dialysis or have known age-specific estimated glomerular filtration rate (egfr) or estimated creatinine clearance (ecrcl) \<30 ml/min/1.73 m2 at screening as measured by a serum creatinine point of care device * oxygen saturation of \<92% on room air obtained at rest within 24 hours prior to randomization * current use of any prohibited concomitant medication(s) * females who are pregnant and \<14 weeks gestation

* current need for hospitalization or anticipated need for hospitalization within 24 h after randomization * known medical history of active liver disease * known hiv infection with a viral load \>400 copies/ml or taking prohibited medications for human immunodeficiency virus (hiv) * receiving dialysis or have known age-specific estimated glomerular filtration rate (egfr) or estimated creatinine clearance (ecrcl) \<30 ml/min/1.73 m2 at screening as measured by a serum creatinine point of care device * oxygen saturation of \<92% on room air obtained at rest within 24 hours prior to randomization * current use of any prohibited concomitant medication(s) * females who are pregnant and \<14 weeks gestation

current need for hospitalization or anticipated need for hospitalization within 24 h after randomization known medical history of active liver disease known hiv infection with a viral load >400 copies/ml or taking prohibited medications for human immunodeficiency virus (hiv) receiving dialysis or have known age-specific estimated glomerular filtration rate (egfr) or estimated creatinine clearance (ecrcl) <30 ml/min/1.73 m2 at screening as measured by a serum creatinine point of care device oxygen saturation of <92% on room air obtained at rest within 24 hours prior to randomization current use of any prohibited concomitant medication(s) females who are pregnant and <14 weeks gestation

current need for hospitalization or anticipated need for hospitalization within 24 h after randomization known medical history of active liver disease known hiv infection with a viral load >400 copies/ml or taking prohibited medications for human immunodeficiency virus (hiv) receiving dialysis or have known age-specific estimated glomerular filtration rate (egfr) or estimated creatinine clearance (ecrcl) <30 ml/min/1.73 m2 at screening as measured by a serum creatinine point of care device oxygen saturation of <92% on room air obtained at rest within 24 hours prior to randomization current use of any prohibited concomitant medication(s) females who are pregnant and <14 weeks gestation