inclusion criteria: 1. healthy subjects aged 18 years old and above. 2. by asking for medical history and physical examination, the investigator judged that the health condition is well. 3. female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. 4. during the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan. 5. with self-ability to understand the study procedures, the informed consent \& voluntarily sign an informed consent form and be able to comply with the requirements of the clinical study protocol.

inclusion criteria: 1. healthy subjects aged 18 years old and above. 2. by asking for medical history and physical examination, the investigator judged that the health condition is well. 3. female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. 4. during the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan. 5. with self-ability to understand the study procedures, the informed consent \& voluntarily sign an informed consent form and be able to comply with the requirements of the clinical study protocol.

inclusion criteria: healthy subjects aged 18 years old and above. by asking for medical history and physical examination, the investigator judged that the health condition is well. female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. during the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan. with self-ability to understand the study procedures, the informed consent & voluntarily sign an informed consent form and be able to comply with the requirements of the clinical study protocol.

inclusion criteria: healthy subjects aged 18 years old and above. by asking for medical history and physical examination, the investigator judged that the health condition is well. female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. during the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan. with self-ability to understand the study procedures, the informed consent & voluntarily sign an informed consent form and be able to comply with the requirements of the clinical study protocol.

inclusion criteria: 1. healthy subjects aged 18 years old and above. 2. by asking for medical history and physical examination, the investigator judged that the health condition is well. 3. female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. 4. during the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan. 5. with self-ability to understand the study procedures, the informed consent & voluntarily sign an informed consent form and be able to comply with the requirements of the clinical study protocol.

inclusion criteria: 1. healthy subjects aged 18 years old and above. 2. by asking for medical history and physical examination, the investigator judged that the health condition is well. 3. female subjects of childbearing age are not nursing or pregnant at the time of enrolment (negative urine pregnancy test) and have no family planning within the first 3 months after enrolment. effective contraceptive measures have been taken within 2 weeks before inclusion. 4. during the whole follow-up period of the study, be able and willing to complete the whole prescribed study plan. 5. with self-ability to understand the study procedures, the informed consent & voluntarily sign an informed consent form and be able to comply with the requirements of the clinical study protocol.