* contraindications for use of corticosteroids; * immunosuppressive, cytotoxic and antiviral treatment, experimental medications and chronic corticosteroid use; * morbid obesity (bmi\> 35); * multiple organ dysfunction syndrome; * pre-malignant neoplastic conditions with life expectancy lower than 1 year old; * pre-existing chronic illnesses like chronic dialysis kidney disease, chronic liver disease, congestive heart failure class iv; pulmonary hypertension (who class iii/iv); * pre-existing or current thromboembolic pathology; * transplanted patients; * pre-existing severe allergic reaction; * history of hiv and tuberculosis; * enrollment in another clinical trial; * pregnancy or breastfeeding.

* contraindications for use of corticosteroids; * immunosuppressive, cytotoxic and antiviral treatment, experimental medications and chronic corticosteroid use; * morbid obesity (bmi\> 35); * multiple organ dysfunction syndrome; * pre-malignant neoplastic conditions with life expectancy lower than 1 year old; * pre-existing chronic illnesses like chronic dialysis kidney disease, chronic liver disease, congestive heart failure class iv; pulmonary hypertension (who class iii/iv); * pre-existing or current thromboembolic pathology; * transplanted patients; * pre-existing severe allergic reaction; * history of hiv and tuberculosis; * enrollment in another clinical trial; * pregnancy or breastfeeding.

contraindications for use of corticosteroids; immunosuppressive, cytotoxic and antiviral treatment, experimental medications and chronic corticosteroid use; morbid obesity (bmi> 35); multiple organ dysfunction syndrome; pre-malignant neoplastic conditions with life expectancy lower than 1 year old; pre-existing chronic illnesses like chronic dialysis kidney disease, chronic liver disease, congestive heart failure class iv; pulmonary hypertension (who class iii/iv); pre-existing or current thromboembolic pathology; transplanted patients; pre-existing severe allergic reaction; history of hiv and tuberculosis; enrollment in another clinical trial; pregnancy or breastfeeding.

contraindications for use of corticosteroids; immunosuppressive, cytotoxic and antiviral treatment, experimental medications and chronic corticosteroid use; morbid obesity (bmi> 35); multiple organ dysfunction syndrome; pre-malignant neoplastic conditions with life expectancy lower than 1 year old; pre-existing chronic illnesses like chronic dialysis kidney disease, chronic liver disease, congestive heart failure class iv; pulmonary hypertension (who class iii/iv); pre-existing or current thromboembolic pathology; transplanted patients; pre-existing severe allergic reaction; history of hiv and tuberculosis; enrollment in another clinical trial; pregnancy or breastfeeding.