inclusion criteria: 1. subjects with voluntary signing of the informed consent form (icf); 2. healthy males or females aged ≥ 18 and ≤ 60 years at the time of signing the icf; 3. subjects with body weight ≥ 50 kg and body mass index (bmi) must be higher than 18.5 kg/m2 and lower than 30 kg/m2 at screening visit ; 4. subjects who are determined to be in good health according to medical history, normal (site normal ranges to be followed) or abnormal but clinically insignificant physical examination, vital signs, ecg, laboratory test results (including hematology, serum chemistry, coagulation function, urinalysis, etc.), and investigator's clinical judgment (ctcae grade 1 of triglycerides and uric acid is permitted). one re-test allowed per investigator discretion to confim result. 5. subject who agrees that he and his spouse or partner will use reliable contraception for 9 months after administration.

inclusion criteria: 1. subjects with voluntary signing of the informed consent form (icf); 2. healthy males or females aged ≥ 18 and ≤ 60 years at the time of signing the icf; 3. subjects with body weight ≥ 50 kg and body mass index (bmi) must be higher than 18.5 kg/m2 and lower than 30 kg/m2 at screening visit ; 4. subjects who are determined to be in good health according to medical history, normal (site normal ranges to be followed) or abnormal but clinically insignificant physical examination, vital signs, ecg, laboratory test results (including hematology, serum chemistry, coagulation function, urinalysis, etc.), and investigator's clinical judgment (ctcae grade 1 of triglycerides and uric acid is permitted). one re-test allowed per investigator discretion to confim result. 5. subject who agrees that he and his spouse or partner will use reliable contraception for 9 months after administration.

inclusion criteria: subjects with voluntary signing of the informed consent form (icf); healthy males or females aged ≥ 18 and ≤ 60 years at the time of signing the icf; subjects with body weight ≥ 50 kg and body mass index (bmi) must be higher than 18.5 kg/m2 and lower than 30 kg/m2 at screening visit ; subjects who are determined to be in good health according to medical history, normal (site normal ranges to be followed) or abnormal but clinically insignificant physical examination, vital signs, ecg, laboratory test results (including hematology, serum chemistry, coagulation function, urinalysis, etc.), and investigator's clinical judgment (ctcae grade 1 of triglycerides and uric acid is permitted). one re-test allowed per investigator discretion to confim result. subject who agrees that he and his spouse or partner will use reliable contraception for 9 months after administration.

inclusion criteria: subjects with voluntary signing of the informed consent form (icf); healthy males or females aged ≥ 18 and ≤ 60 years at the time of signing the icf; subjects with body weight ≥ 50 kg and body mass index (bmi) must be higher than 18.5 kg/m2 and lower than 30 kg/m2 at screening visit ; subjects who are determined to be in good health according to medical history, normal (site normal ranges to be followed) or abnormal but clinically insignificant physical examination, vital signs, ecg, laboratory test results (including hematology, serum chemistry, coagulation function, urinalysis, etc.), and investigator's clinical judgment (ctcae grade 1 of triglycerides and uric acid is permitted). one re-test allowed per investigator discretion to confim result. subject who agrees that he and his spouse or partner will use reliable contraception for 9 months after administration.