* documented history of covid-19 within 6 months prior to enrollment. * positive reverse transcription - polymerase chain reaction (rt-pcr) test for sars-cov-2 within 2 days of screening * received any covid-19 vaccine other than bnt162b2 or mrna-1273. * received more than 3 doses of any mrna covid-19 vaccine. * pregnant or breastfeeding or intending to become pregnant or father children within the projected duration of the trial. * currently working in an occupation with a high risk of exposure to sars-cov-2 (eg, healthcare worker, emergency response personnel having direct interactions with or providing direct care to patients). * history of infection of middle east respiratory syndrome (mers), or severe acute respiratory syndrome (sars). * positive serology test results for hepatitis c virus antibody, hiv antibody, hepatitis b virus surface antigen at screening. * currently taking marketed, investigational, off-label product for the prevention of mers, sars, or covid-19. * is currently participating in or has participated in a study with an investigational product within 30 days preceding day 1. * fever (tympanic temperature \> 37.5 degree c), dry cough, fatigue, nasal obstruction, runny nose, sore throat, myalgia, diarrhea, shortness of breath or dyspnea within 14 days before administration * abnormal indicators, such as blood biochemistry, blood routine and urine routine deemed clinically significant by the investigator, or the value is beyond grade 1 per toxicity grading scale. * history of severe allergic reactions (such as acute anaphylaxis, urticaria, skin eczema, dyspnea, angioneurotic edema or abdominal pain) or allergy to known composition of rvm-v001 vaccine. * history of convulsion, epilepsy, encephalopathy or severe mental illness. * diagnosed with congenital malformations or developmental disorders, genetic defects, severe malnutrition. * diagnosed with severe liver and kidney diseases, uncontrollable hypertension (systolic pressure \>140 mmhg, diastolic pressure \>90 mmhg), diabetic complications, malignant tumors, acute viral or bacterial infections or acute onset of chronic disease. * diagnosed with congenital or acquired immune deficiency, hiv infection, lymphoma, leukemia or other autoimmune diseases * history of coagulation dysfunction (eg, coagulation factor deficiency, coagulation disease). * vaccinated with live attenuated vaccine within 1 month, or other vaccine within 14 days before vaccination. * receiving immunotherapy or inhibitor therapy within 3 months (consistently oral or infusion for more than 14 days). * received systemic immunosuppressants within 4 months prior to vaccination or anticipating the need for immunosuppressant at any time during participation in the study. topical or inhaled treatment is allowed if not used within 14 days prior to vaccination. * receiving blood products within 3 months before administration * history of alcohol or drug abuse within 3 years before first vaccination. * has donated 450ml or greater of blood within 28 days prior to vaccination. * history of anaphylaxis or angioedema including but not limited to history of anaphylaxis after any vaccine. * any condition that, in the opinion of the investigator, would pose a health risk to the subject if enrolled or could interfere with evaluation of the study vaccine or has interpretation of study results (including neurologic or psychiatric conditions deemed likely to impair the quality of safety reporting).

* documented history of covid-19 within 6 months prior to enrollment. * positive reverse transcription - polymerase chain reaction (rt-pcr) test for sars-cov-2 within 2 days of screening * received any covid-19 vaccine other than bnt162b2 or mrna-1273. * received more than 3 doses of any mrna covid-19 vaccine. * pregnant or breastfeeding or intending to become pregnant or father children within the projected duration of the trial. * currently working in an occupation with a high risk of exposure to sars-cov-2 (eg, healthcare worker, emergency response personnel having direct interactions with or providing direct care to patients). * history of infection of middle east respiratory syndrome (mers), or severe acute respiratory syndrome (sars). * positive serology test results for hepatitis c virus antibody, hiv antibody, hepatitis b virus surface antigen at screening. * currently taking marketed, investigational, off-label product for the prevention of mers, sars, or covid-19. * is currently participating in or has participated in a study with an investigational product within 30 days preceding day 1. * fever (tympanic temperature \> 37.5 degree c), dry cough, fatigue, nasal obstruction, runny nose, sore throat, myalgia, diarrhea, shortness of breath or dyspnea within 14 days before administration * abnormal indicators, such as blood biochemistry, blood routine and urine routine deemed clinically significant by the investigator, or the value is beyond grade 1 per toxicity grading scale. * history of severe allergic reactions (such as acute anaphylaxis, urticaria, skin eczema, dyspnea, angioneurotic edema or abdominal pain) or allergy to known composition of rvm-v001 vaccine. * history of convulsion, epilepsy, encephalopathy or severe mental illness. * diagnosed with congenital malformations or developmental disorders, genetic defects, severe malnutrition. * diagnosed with severe liver and kidney diseases, uncontrollable hypertension (systolic pressure \>140 mmhg, diastolic pressure \>90 mmhg), diabetic complications, malignant tumors, acute viral or bacterial infections or acute onset of chronic disease. * diagnosed with congenital or acquired immune deficiency, hiv infection, lymphoma, leukemia or other autoimmune diseases * history of coagulation dysfunction (eg, coagulation factor deficiency, coagulation disease). * vaccinated with live attenuated vaccine within 1 month, or other vaccine within 14 days before vaccination. * receiving immunotherapy or inhibitor therapy within 3 months (consistently oral or infusion for more than 14 days). * received systemic immunosuppressants within 4 months prior to vaccination or anticipating the need for immunosuppressant at any time during participation in the study. topical or inhaled treatment is allowed if not used within 14 days prior to vaccination. * receiving blood products within 3 months before administration * history of alcohol or drug abuse within 3 years before first vaccination. * has donated 450ml or greater of blood within 28 days prior to vaccination. * history of anaphylaxis or angioedema including but not limited to history of anaphylaxis after any vaccine. * any condition that, in the opinion of the investigator, would pose a health risk to the subject if enrolled or could interfere with evaluation of the study vaccine or has interpretation of study results (including neurologic or psychiatric conditions deemed likely to impair the quality of safety reporting).

documented history of covid-19 within 6 months prior to enrollment. positive reverse transcription - polymerase chain reaction (rt-pcr) test for sars-cov-2 within 2 days of screening received any covid-19 vaccine other than bnt162b2 or mrna-1273. received more than 3 doses of any mrna covid-19 vaccine. pregnant or breastfeeding or intending to become pregnant or father children within the projected duration of the trial. currently working in an occupation with a high risk of exposure to sars-cov-2 (eg, healthcare worker, emergency response personnel having direct interactions with or providing direct care to patients). history of infection of middle east respiratory syndrome (mers), or severe acute respiratory syndrome (sars). positive serology test results for hepatitis c virus antibody, hiv antibody, hepatitis b virus surface antigen at screening. currently taking marketed, investigational, off-label product for the prevention of mers, sars, or covid-19. is currently participating in or has participated in a study with an investigational product within 30 days preceding day 1. fever (tympanic temperature > 37.5 degree c), dry cough, fatigue, nasal obstruction, runny nose, sore throat, myalgia, diarrhea, shortness of breath or dyspnea within 14 days before administration abnormal indicators, such as blood biochemistry, blood routine and urine routine deemed clinically significant by the investigator, or the value is beyond grade 1 per toxicity grading scale. history of severe allergic reactions (such as acute anaphylaxis, urticaria, skin eczema, dyspnea, angioneurotic edema or abdominal pain) or allergy to known composition of rvm-v001 vaccine. history of convulsion, epilepsy, encephalopathy or severe mental illness. diagnosed with congenital malformations or developmental disorders, genetic defects, severe malnutrition. diagnosed with severe liver and kidney diseases, uncontrollable hypertension (systolic pressure >140 mmhg, diastolic pressure >90 mmhg), diabetic complications, malignant tumors, acute viral or bacterial infections or acute onset of chronic disease. diagnosed with congenital or acquired immune deficiency, hiv infection, lymphoma, leukemia or other autoimmune diseases history of coagulation dysfunction (eg, coagulation factor deficiency, coagulation disease). vaccinated with live attenuated vaccine within 1 month, or other vaccine within 14 days before vaccination. receiving immunotherapy or inhibitor therapy within 3 months (consistently oral or infusion for more than 14 days). received systemic immunosuppressants within 4 months prior to vaccination or anticipating the need for immunosuppressant at any time during participation in the study. topical or inhaled treatment is allowed if not used within 14 days prior to vaccination. receiving blood products within 3 months before administration history of alcohol or drug abuse within 3 years before first vaccination. has donated 450ml or greater of blood within 28 days prior to vaccination. history of anaphylaxis or angioedema including but not limited to history of anaphylaxis after any vaccine. any condition that, in the opinion of the investigator, would pose a health risk to the subject if enrolled or could interfere with evaluation of the study vaccine or has interpretation of study results (including neurologic or psychiatric conditions deemed likely to impair the quality of safety reporting).

documented history of covid-19 within 6 months prior to enrollment. positive reverse transcription - polymerase chain reaction (rt-pcr) test for sars-cov-2 within 2 days of screening received any covid-19 vaccine other than bnt162b2 or mrna-1273. received more than 3 doses of any mrna covid-19 vaccine. pregnant or breastfeeding or intending to become pregnant or father children within the projected duration of the trial. currently working in an occupation with a high risk of exposure to sars-cov-2 (eg, healthcare worker, emergency response personnel having direct interactions with or providing direct care to patients). history of infection of middle east respiratory syndrome (mers), or severe acute respiratory syndrome (sars). positive serology test results for hepatitis c virus antibody, hiv antibody, hepatitis b virus surface antigen at screening. currently taking marketed, investigational, off-label product for the prevention of mers, sars, or covid-19. is currently participating in or has participated in a study with an investigational product within 30 days preceding day 1. fever (tympanic temperature > 37.5 degree c), dry cough, fatigue, nasal obstruction, runny nose, sore throat, myalgia, diarrhea, shortness of breath or dyspnea within 14 days before administration abnormal indicators, such as blood biochemistry, blood routine and urine routine deemed clinically significant by the investigator, or the value is beyond grade 1 per toxicity grading scale. history of severe allergic reactions (such as acute anaphylaxis, urticaria, skin eczema, dyspnea, angioneurotic edema or abdominal pain) or allergy to known composition of rvm-v001 vaccine. history of convulsion, epilepsy, encephalopathy or severe mental illness. diagnosed with congenital malformations or developmental disorders, genetic defects, severe malnutrition. diagnosed with severe liver and kidney diseases, uncontrollable hypertension (systolic pressure >140 mmhg, diastolic pressure >90 mmhg), diabetic complications, malignant tumors, acute viral or bacterial infections or acute onset of chronic disease. diagnosed with congenital or acquired immune deficiency, hiv infection, lymphoma, leukemia or other autoimmune diseases history of coagulation dysfunction (eg, coagulation factor deficiency, coagulation disease). vaccinated with live attenuated vaccine within 1 month, or other vaccine within 14 days before vaccination. receiving immunotherapy or inhibitor therapy within 3 months (consistently oral or infusion for more than 14 days). received systemic immunosuppressants within 4 months prior to vaccination or anticipating the need for immunosuppressant at any time during participation in the study. topical or inhaled treatment is allowed if not used within 14 days prior to vaccination. receiving blood products within 3 months before administration history of alcohol or drug abuse within 3 years before first vaccination. has donated 450ml or greater of blood within 28 days prior to vaccination. history of anaphylaxis or angioedema including but not limited to history of anaphylaxis after any vaccine. any condition that, in the opinion of the investigator, would pose a health risk to the subject if enrolled or could interfere with evaluation of the study vaccine or has interpretation of study results (including neurologic or psychiatric conditions deemed likely to impair the quality of safety reporting).