* subjects who require immediate hospital admission because of severe covid-19 symptoms at onset according to family doctor's assessment (mews score 5, and/or septic shock, multiorgan failure) * known hypersensitivity or allergy to any medication under investigation * specific contraindications to the use of each recommended drugs according to their summary of product characteristics and the clinical judgment of family doctor * legal incapacity, limited legal incapacity, intellectual disability, uncooperative attitude or any other evidence that the patient will not be able to understand the study aims and procedures * pregnancy\* (\*patient with childbearing potential will be included according to the pragmatic design of the study)

* subjects who require immediate hospital admission because of severe covid-19 symptoms at onset according to family doctor's assessment (mews score 5, and/or septic shock, multiorgan failure) * known hypersensitivity or allergy to any medication under investigation * specific contraindications to the use of each recommended drugs according to their summary of product characteristics and the clinical judgment of family doctor * legal incapacity, limited legal incapacity, intellectual disability, uncooperative attitude or any other evidence that the patient will not be able to understand the study aims and procedures * pregnancy\* (\*patient with childbearing potential will be included according to the pragmatic design of the study)

subjects who require immediate hospital admission because of severe covid-19 symptoms at onset according to family doctor's assessment (mews score 5, and/or septic shock, multiorgan failure) known hypersensitivity or allergy to any medication under investigation specific contraindications to the use of each recommended drugs according to their summary of product characteristics and the clinical judgment of family doctor legal incapacity, limited legal incapacity, intellectual disability, uncooperative attitude or any other evidence that the patient will not be able to understand the study aims and procedures pregnancy* (*patient with childbearing potential will be included according to the pragmatic design of the study)

subjects who require immediate hospital admission because of severe covid-19 symptoms at onset according to family doctor's assessment (mews score 5, and/or septic shock, multiorgan failure) known hypersensitivity or allergy to any medication under investigation specific contraindications to the use of each recommended drugs according to their summary of product characteristics and the clinical judgment of family doctor legal incapacity, limited legal incapacity, intellectual disability, uncooperative attitude or any other evidence that the patient will not be able to understand the study aims and procedures pregnancy* (*patient with childbearing potential will be included according to the pragmatic design of the study)