inclusion criteria: * volunteers must meet the following inclusion criteria: type of participants \* healthy volunteers or volunteers with a history of stable diseases that do not meet any of the criteria for non-inclusion in the study. age at the time of signing the informed consent \* from ≥ 18 to \< 60 years. paul \* male or female. the volunteers of the study group must meet the following additional inclusion criteria: * written informed consent of volunteers to participate in a clinical trial. * volunteers who are able to fulfill protocol requirements (i.e. answer phone calls, fill out a self-observation diary, come to control visits). * for women capable of childbirth - a negative pregnancy test and consent to adhere to adequate methods of contraception (use of contraceptives within a month after the second vaccination). women should use methods of contraception with a reliability of more than 90% (cervical caps with spermicide, diaphragms with spermicide, condoms, intrauterine spirals), or be sterile, or in a postmenopausal state. * for men capable of conception - consent to adhere to adequate methods of contraception (use of contraceptives within a month after the second vaccination). men and their sexual partners should use methods of contraception with a reliability of more than 90% (cervical caps with spermicide, diaphragms with spermicide, condoms, intrauterine spirals), or be sterile.

inclusion criteria: * volunteers must meet the following inclusion criteria: type of participants \* healthy volunteers or volunteers with a history of stable diseases that do not meet any of the criteria for non-inclusion in the study. age at the time of signing the informed consent \* from ≥ 18 to \< 60 years. paul \* male or female. the volunteers of the study group must meet the following additional inclusion criteria: * written informed consent of volunteers to participate in a clinical trial. * volunteers who are able to fulfill protocol requirements (i.e. answer phone calls, fill out a self-observation diary, come to control visits). * for women capable of childbirth - a negative pregnancy test and consent to adhere to adequate methods of contraception (use of contraceptives within a month after the second vaccination). women should use methods of contraception with a reliability of more than 90% (cervical caps with spermicide, diaphragms with spermicide, condoms, intrauterine spirals), or be sterile, or in a postmenopausal state. * for men capable of conception - consent to adhere to adequate methods of contraception (use of contraceptives within a month after the second vaccination). men and their sexual partners should use methods of contraception with a reliability of more than 90% (cervical caps with spermicide, diaphragms with spermicide, condoms, intrauterine spirals), or be sterile.

inclusion criteria: volunteers must meet the following inclusion criteria: type of participants * healthy volunteers or volunteers with a history of stable diseases that do not meet any of the criteria for non-inclusion in the study. age at the time of signing the informed consent * from ≥ 18 to < 60 years. paul * male or female. the volunteers of the study group must meet the following additional inclusion criteria: written informed consent of volunteers to participate in a clinical trial. volunteers who are able to fulfill protocol requirements (i.e. answer phone calls, fill out a self-observation diary, come to control visits). for women capable of childbirth - a negative pregnancy test and consent to adhere to adequate methods of contraception (use of contraceptives within a month after the second vaccination). women should use methods of contraception with a reliability of more than 90% (cervical caps with spermicide, diaphragms with spermicide, condoms, intrauterine spirals), or be sterile, or in a postmenopausal state. for men capable of conception - consent to adhere to adequate methods of contraception (use of contraceptives within a month after the second vaccination). men and their sexual partners should use methods of contraception with a reliability of more than 90% (cervical caps with spermicide, diaphragms with spermicide, condoms, intrauterine spirals), or be sterile.

inclusion criteria: volunteers must meet the following inclusion criteria: type of participants * healthy volunteers or volunteers with a history of stable diseases that do not meet any of the criteria for non-inclusion in the study. age at the time of signing the informed consent * from ≥ 18 to < 60 years. paul * male or female. the volunteers of the study group must meet the following additional inclusion criteria: written informed consent of volunteers to participate in a clinical trial. volunteers who are able to fulfill protocol requirements (i.e. answer phone calls, fill out a self-observation diary, come to control visits). for women capable of childbirth - a negative pregnancy test and consent to adhere to adequate methods of contraception (use of contraceptives within a month after the second vaccination). women should use methods of contraception with a reliability of more than 90% (cervical caps with spermicide, diaphragms with spermicide, condoms, intrauterine spirals), or be sterile, or in a postmenopausal state. for men capable of conception - consent to adhere to adequate methods of contraception (use of contraceptives within a month after the second vaccination). men and their sexual partners should use methods of contraception with a reliability of more than 90% (cervical caps with spermicide, diaphragms with spermicide, condoms, intrauterine spirals), or be sterile.