inclusion criteria: * adult healthcare workers (hcws) (for instance physicians, nurses, assistant nurses, dentists, physiotherapists, midwives, etc.) * hcw involved at the time of enrolment in the care and the management of patients with confirmed or suspected sars-cov-2 infection in hospital settings, in outpatient care settings or in geriatric long-term care facilities. these hcws have prolonged or repeated close contact to these patients. * hcw tested negative for hiv * hcw affiliated to the french health insurance system * hcw women of childbearing age with an effective contraception (ethinylestradiol-containing contraceptive pills are not regarded as effective in the context of lpv/r treatment - covidaxis 2) * willing to comply to study design and the follow-up * consent form signed

inclusion criteria: * adult healthcare workers (hcws) (for instance physicians, nurses, assistant nurses, dentists, physiotherapists, midwives, etc.) * hcw involved at the time of enrolment in the care and the management of patients with confirmed or suspected sars-cov-2 infection in hospital settings, in outpatient care settings or in geriatric long-term care facilities. these hcws have prolonged or repeated close contact to these patients. * hcw tested negative for hiv * hcw affiliated to the french health insurance system * hcw women of childbearing age with an effective contraception (ethinylestradiol-containing contraceptive pills are not regarded as effective in the context of lpv/r treatment - covidaxis 2) * willing to comply to study design and the follow-up * consent form signed

inclusion criteria: - adult healthcare workers (hcws) (for instance physicians, nurses, assistant nurses, dentists, physiotherapists, midwives, etc.) - hcw involved at the time of enrolment in the care and the management of patients with confirmed or suspected sars-cov-2 infection in hospital settings, in outpatient care settings or in geriatric long-term care facilities. these hcws have prolonged or repeated close contact to these patients. - hcw tested negative for hiv - hcw affiliated to the french health insurance system - hcw women of childbearing age with an effective contraception (ethinylestradiol-containing contraceptive pills are not regarded as effective in the context of lpv/r treatment - covidaxis 2) - willing to comply to study design and the follow-up - consent form signed

inclusion criteria: - adult healthcare workers (hcws) (for instance physicians, nurses, assistant nurses, dentists, physiotherapists, midwives, etc.) - hcw involved at the time of enrolment in the care and the management of patients with confirmed or suspected sars-cov-2 infection in hospital settings, in outpatient care settings or in geriatric long-term care facilities. these hcws have prolonged or repeated close contact to these patients. - hcw tested negative for hiv - hcw affiliated to the french health insurance system - hcw women of childbearing age with an effective contraception (ethinylestradiol-containing contraceptive pills are not regarded as effective in the context of lpv/r treatment - covidaxis 2) - willing to comply to study design and the follow-up - consent form signed