for covidaxis 1: * hcw with positive sars-cov-2 rt-pcr of nasopharyngeal swab at the inclusion visit. * hcw with past history of confirmed sars-cov-2 infection * hcw with positive sars-cov-2 serology at the inclusion visit * hcw with comorbidities such as hypothyroidism that need hormonal substitution, or retinopathy or with prior intermittent porphyria, or chronic renal failure (glomerular filtration rate \< 30ml/min) or prior hepatic failure or psoriasis. * hcw with prior diagnosis of glucose-6-phosphate dehydrogenase (g6pd) deficiency * hcw with known hypersensitivity/allergy to hcq * hcw with baseline qtc interval \> 450ms in men or \> 460ms in women and qtc \<320 ms (both gender) * hcw with personal or family history of long qt syndrome, torsades de pointes, or sudden death * pregnant hcw * breastfeeding hcw * hcw taking comedications known to have interactions with hcq according to the official characteristics of the product for covidaxis 2: * hcw with positive sars-cov-2 rt-pcr of nasopharyngeal swab at the inclusion visit. * hcw with past history of confirmed sars-cov-2 infection * hcw with positive sars-cov-2 serology at the inclusion visit * hcw with comorbidities such as chronic hcv infection treated by direct antiviral drugs or with hypothyroidism that need hormonal substitution, or known to have hypercholesterolemia hypertriglyceridemiaor chronic renal failure (glomerular filtration rate \< 30ml/min) or prior hepatic failure * hcw with known hypersensitivity/allergy to lpv/r * hcw with baseline qtc interval \> 450ms in men or \> 460ms in women and qtc \<320 ms (both gender) * hcw with personal or family history of long qt syndrome, torsades de pointes, or sudden death * pregnant hcw * breastfeeding hcw * hcw taking comedications known to have interactions with lpv/r according to the official characteristics of the product

for covidaxis 1: * hcw with positive sars-cov-2 rt-pcr of nasopharyngeal swab at the inclusion visit. * hcw with past history of confirmed sars-cov-2 infection * hcw with positive sars-cov-2 serology at the inclusion visit * hcw with comorbidities such as hypothyroidism that need hormonal substitution, or retinopathy or with prior intermittent porphyria, or chronic renal failure (glomerular filtration rate \< 30ml/min) or prior hepatic failure or psoriasis. * hcw with prior diagnosis of glucose-6-phosphate dehydrogenase (g6pd) deficiency * hcw with known hypersensitivity/allergy to hcq * hcw with baseline qtc interval \> 450ms in men or \> 460ms in women and qtc \<320 ms (both gender) * hcw with personal or family history of long qt syndrome, torsades de pointes, or sudden death * pregnant hcw * breastfeeding hcw * hcw taking comedications known to have interactions with hcq according to the official characteristics of the product for covidaxis 2: * hcw with positive sars-cov-2 rt-pcr of nasopharyngeal swab at the inclusion visit. * hcw with past history of confirmed sars-cov-2 infection * hcw with positive sars-cov-2 serology at the inclusion visit * hcw with comorbidities such as chronic hcv infection treated by direct antiviral drugs or with hypothyroidism that need hormonal substitution, or known to have hypercholesterolemia hypertriglyceridemiaor chronic renal failure (glomerular filtration rate \< 30ml/min) or prior hepatic failure * hcw with known hypersensitivity/allergy to lpv/r * hcw with baseline qtc interval \> 450ms in men or \> 460ms in women and qtc \<320 ms (both gender) * hcw with personal or family history of long qt syndrome, torsades de pointes, or sudden death * pregnant hcw * breastfeeding hcw * hcw taking comedications known to have interactions with lpv/r according to the official characteristics of the product

for covidaxis 1: - hcw with positive sars-cov-2 rt-pcr of nasopharyngeal swab at the inclusion visit. - hcw with past history of confirmed sars-cov-2 infection - hcw with positive sars-cov-2 serology at the inclusion visit - hcw with comorbidities such as hypothyroidism that need hormonal substitution, or retinopathy or with prior intermittent porphyria, or chronic renal failure (glomerular filtration rate < 30ml/min) or prior hepatic failure or psoriasis. - hcw with prior diagnosis of glucose-6-phosphate dehydrogenase (g6pd) deficiency - hcw with known hypersensitivity/allergy to hcq - hcw with baseline qtc interval > 450ms in men or > 460ms in women and qtc <320 ms (both gender) - hcw with personal or family history of long qt syndrome, torsades de pointes, or sudden death - pregnant hcw - breastfeeding hcw - hcw taking comedications known to have interactions with hcq according to the official characteristics of the product for covidaxis 2: - hcw with positive sars-cov-2 rt-pcr of nasopharyngeal swab at the inclusion visit. - hcw with past history of confirmed sars-cov-2 infection - hcw with positive sars-cov-2 serology at the inclusion visit - hcw with comorbidities such as chronic hcv infection treated by direct antiviral drugs or with hypothyroidism that need hormonal substitution, or known to have hypercholesterolemia hypertriglyceridemiaor chronic renal failure (glomerular filtration rate < 30ml/min) or prior hepatic failure - hcw with known hypersensitivity/allergy to lpv/r - hcw with baseline qtc interval > 450ms in men or > 460ms in women and qtc <320 ms (both gender) - hcw with personal or family history of long qt syndrome, torsades de pointes, or sudden death - pregnant hcw - breastfeeding hcw - hcw taking comedications known to have interactions with lpv/r according to the official characteristics of the product

for covidaxis 1: - hcw with positive sars-cov-2 rt-pcr of nasopharyngeal swab at the inclusion visit. - hcw with past history of confirmed sars-cov-2 infection - hcw with positive sars-cov-2 serology at the inclusion visit - hcw with comorbidities such as hypothyroidism that need hormonal substitution, or retinopathy or with prior intermittent porphyria, or chronic renal failure (glomerular filtration rate < 30ml/min) or prior hepatic failure or psoriasis. - hcw with prior diagnosis of glucose-6-phosphate dehydrogenase (g6pd) deficiency - hcw with known hypersensitivity/allergy to hcq - hcw with baseline qtc interval > 450ms in men or > 460ms in women and qtc <320 ms (both gender) - hcw with personal or family history of long qt syndrome, torsades de pointes, or sudden death - pregnant hcw - breastfeeding hcw - hcw taking comedications known to have interactions with hcq according to the official characteristics of the product for covidaxis 2: - hcw with positive sars-cov-2 rt-pcr of nasopharyngeal swab at the inclusion visit. - hcw with past history of confirmed sars-cov-2 infection - hcw with positive sars-cov-2 serology at the inclusion visit - hcw with comorbidities such as chronic hcv infection treated by direct antiviral drugs or with hypothyroidism that need hormonal substitution, or known to have hypercholesterolemia hypertriglyceridemiaor chronic renal failure (glomerular filtration rate < 30ml/min) or prior hepatic failure - hcw with known hypersensitivity/allergy to lpv/r - hcw with baseline qtc interval > 450ms in men or > 460ms in women and qtc <320 ms (both gender) - hcw with personal or family history of long qt syndrome, torsades de pointes, or sudden death - pregnant hcw - breastfeeding hcw - hcw taking comedications known to have interactions with lpv/r according to the official characteristics of the product