1. Patients with unstable disease activity and past history of flare <br/ >following vaccinations. <br/ >2. Patients with non-repopulated peripheral B cell <br/ >3. Patients with history of allergic reaction to vaccine or its <br/ >components <br/ >4. Patients who received live vaccine within 2 months prior the study

1. Patients with unstable disease activity and past history of flare <br/ >following vaccinations. <br/ >2. Patients with non-repopulated peripheral B cell <br/ >3. Patients with history of allergic reaction to vaccine or its <br/ >components <br/ >4. Patients who received live vaccine within 2 months prior the study