inclusion criteria: 1. healthy participants 18-59 years, and both males and females should be included; 2. participants who agree to participate in this clinical trial voluntarily and sign the informed consent form, capable of providing valid identification, understanding and complying with the requirements of the clinical protocol. 3. for female participants of childbearing potential, effective contraception measures should be used within 2 weeks prior to participation in this study and the results of the pregnancy test must be negative. participants must voluntarily agree to use effective contraceptive measures from the time of signing the informed consent to the end of the study (effective contraceptive measures including oral contraceptives (excluding emergency contraceptives), injectable or implantable contraceptives, sustained-release topical contraceptives, hormonal patches, intrauterine device, sterilization, abstinence, condoms (for males), diaphragms, cervical caps, etc.). 4. body mass index within range of 18\~30 kg/m2

inclusion criteria: 1. healthy participants 18-59 years, and both males and females should be included; 2. participants who agree to participate in this clinical trial voluntarily and sign the informed consent form, capable of providing valid identification, understanding and complying with the requirements of the clinical protocol. 3. for female participants of childbearing potential, effective contraception measures should be used within 2 weeks prior to participation in this study and the results of the pregnancy test must be negative. participants must voluntarily agree to use effective contraceptive measures from the time of signing the informed consent to the end of the study (effective contraceptive measures including oral contraceptives (excluding emergency contraceptives), injectable or implantable contraceptives, sustained-release topical contraceptives, hormonal patches, intrauterine device, sterilization, abstinence, condoms (for males), diaphragms, cervical caps, etc.). 4. body mass index within range of 18\~30 kg/m2

inclusion criteria: healthy participants 18-59 years, and both males and females should be included; participants who agree to participate in this clinical trial voluntarily and sign the informed consent form, capable of providing valid identification, understanding and complying with the requirements of the clinical protocol. for female participants of childbearing potential, effective contraception measures should be used within 2 weeks prior to participation in this study and the results of the pregnancy test must be negative. participants must voluntarily agree to use effective contraceptive measures from the time of signing the informed consent to the end of the study (effective contraceptive measures including oral contraceptives (excluding emergency contraceptives), injectable or implantable contraceptives, sustained-release topical contraceptives, hormonal patches, intrauterine device, sterilization, abstinence, condoms (for males), diaphragms, cervical caps, etc.). body mass index within range of 18~30 kg/m2

inclusion criteria: healthy participants 18-59 years, and both males and females should be included; participants who agree to participate in this clinical trial voluntarily and sign the informed consent form, capable of providing valid identification, understanding and complying with the requirements of the clinical protocol. for female participants of childbearing potential, effective contraception measures should be used within 2 weeks prior to participation in this study and the results of the pregnancy test must be negative. participants must voluntarily agree to use effective contraceptive measures from the time of signing the informed consent to the end of the study (effective contraceptive measures including oral contraceptives (excluding emergency contraceptives), injectable or implantable contraceptives, sustained-release topical contraceptives, hormonal patches, intrauterine device, sterilization, abstinence, condoms (for males), diaphragms, cervical caps, etc.). body mass index within range of 18~30 kg/m2