inclusion criteria: * over 18 years old * male or female * patients with documented pcr sars-cov-2 positive test obtained during the course of the disease * convalescent covid-19 patient (define as at least 10 days after the onset of symptoms, no fever for at least 24 hours without the use of antipyretics and improvement of respiratory symptoms according to the quick covid-19 severity index (qcsi). * signature of informed consent. * moderate or worst clinical severity presentations of covid-19. (according to the world health organization clinical progression scale) * risk of health complication \>50% according to the health risk calculator

inclusion criteria: * over 18 years old * male or female * patients with documented pcr sars-cov-2 positive test obtained during the course of the disease * convalescent covid-19 patient (define as at least 10 days after the onset of symptoms, no fever for at least 24 hours without the use of antipyretics and improvement of respiratory symptoms according to the quick covid-19 severity index (qcsi). * signature of informed consent. * moderate or worst clinical severity presentations of covid-19. (according to the world health organization clinical progression scale) * risk of health complication \>50% according to the health risk calculator

inclusion criteria: over 18 years old male or female patients with documented pcr sars-cov-2 positive test obtained during the course of the disease convalescent covid-19 patient (define as at least 10 days after the onset of symptoms, no fever for at least 24 hours without the use of antipyretics and improvement of respiratory symptoms according to the quick covid-19 severity index (qcsi). signature of informed consent. moderate or worst clinical severity presentations of covid-19. (according to the world health organization clinical progression scale) risk of health complication >50% according to the health risk calculator

inclusion criteria: over 18 years old male or female patients with documented pcr sars-cov-2 positive test obtained during the course of the disease convalescent covid-19 patient (define as at least 10 days after the onset of symptoms, no fever for at least 24 hours without the use of antipyretics and improvement of respiratory symptoms according to the quick covid-19 severity index (qcsi). signature of informed consent. moderate or worst clinical severity presentations of covid-19. (according to the world health organization clinical progression scale) risk of health complication >50% according to the health risk calculator