1. Subjects aged 18 years and older, 2. Subjects capable of understanding and voluntarily signing the informed consent, 3. Subjects with general good health as judged by medical history and physical examination. General good health was defined as no significant change of treatment or hospitalization due to disease deterioration within 3 months prior to enrollment, 4. Women of childbearing age presented with a negative pregnancy test result prior to vaccination, and who voluntarily agree to take effective contraceptive measures (including: oral contraceptives (excluding emergency contraceptives), injectable or implantable contraception, extended-release topical contraceptives, hormonal patches, intrauterine devices, sterilization, abstinence, condoms (male), diaphragms, cervical caps, etc.) from the time of signing the informed consent until the end of the study.

1. Subjects aged 18 years and older, 2. Subjects capable of understanding and voluntarily signing the informed consent, 3. Subjects with general good health as judged by medical history and physical examination. General good health was defined as no significant change of treatment or hospitalization due to disease deterioration within 3 months prior to enrollment, 4. Women of childbearing age presented with a negative pregnancy test result prior to vaccination, and who voluntarily agree to take effective contraceptive measures (including: oral contraceptives (excluding emergency contraceptives), injectable or implantable contraception, extended-release topical contraceptives, hormonal patches, intrauterine devices, sterilization, abstinence, condoms (male), diaphragms, cervical caps, etc.) from the time of signing the informed consent until the end of the study.