inclusion criteria: * willing to provide informed consent and able to comply with protocol requirements * 18 years or older * has a covid-19 diagnosis confirmed by pcr * hospitalized within 5 days and meets the following criteria at screening: peripheral capillary oxygen saturation (spo2) ≤ 93% on room air or spo2 ≥93% on ≤10 liters per minute of supplemental oxygen via nasal cannula * radiographic (chest x-ray, computed tomography scan, or ultrasound) evidence of bilateral pulmonary infiltrates consistent with sars-cov-2/covid-19 * clinical symptoms consistent with covid-19 per investigator judgement * body mass index between 18 to 40 kg/m2 * if of reproductive potential, willing to abstain or agree to the use of highly effective contraception

inclusion criteria: * willing to provide informed consent and able to comply with protocol requirements * 18 years or older * has a covid-19 diagnosis confirmed by pcr * hospitalized within 5 days and meets the following criteria at screening: peripheral capillary oxygen saturation (spo2) ≤ 93% on room air or spo2 ≥93% on ≤10 liters per minute of supplemental oxygen via nasal cannula * radiographic (chest x-ray, computed tomography scan, or ultrasound) evidence of bilateral pulmonary infiltrates consistent with sars-cov-2/covid-19 * clinical symptoms consistent with covid-19 per investigator judgement * body mass index between 18 to 40 kg/m2 * if of reproductive potential, willing to abstain or agree to the use of highly effective contraception

inclusion criteria: - willing to provide informed consent and able to comply with protocol requirements - 18 years or older - has a covid-19 diagnosis confirmed by pcr - hospitalized within 5 days and meets the following criteria at screening: peripheral capillary oxygen saturation (spo2) ≤ 93% on room air or spo2 ≥93% on ≤10 liters per minute of supplemental oxygen via nasal cannula - radiographic (chest x-ray, computed tomography scan, or ultrasound) evidence of bilateral pulmonary infiltrates consistent with sars-cov-2/covid-19 - clinical symptoms consistent with covid-19 per investigator judgement - body mass index between 18 to 40 kg/m2 - if of reproductive potential, willing to abstain or agree to the use of highly effective contraception

inclusion criteria: - willing to provide informed consent and able to comply with protocol requirements - 18 years or older - has a covid-19 diagnosis confirmed by pcr - hospitalized within 5 days and meets the following criteria at screening: peripheral capillary oxygen saturation (spo2) ≤ 93% on room air or spo2 ≥93% on ≤10 liters per minute of supplemental oxygen via nasal cannula - radiographic (chest x-ray, computed tomography scan, or ultrasound) evidence of bilateral pulmonary infiltrates consistent with sars-cov-2/covid-19 - clinical symptoms consistent with covid-19 per investigator judgement - body mass index between 18 to 40 kg/m2 - if of reproductive potential, willing to abstain or agree to the use of highly effective contraception