1. Asymptomatic patient 2. Patient with severe symptom (on high flow nasal canular oxygen or above) 3. Pregnancy women 4. Lactating women 5. Chronic liver disease 6. Meningitis patient 7. Epilepsy who on barbiturate, benzodiazepine or valproic aside as medication 8. Who can&#039,t tolerate to oral feeding 9. Who participate other experimental drugs 10. Who had symptom that might mimicking severe drug adverse reaction (uncontrollable nausea/vomitting, liver function test 3 times UNL or above) 11. Who wish not to participate the study

1. Asymptomatic patient 2. Patient with severe symptom (on high flow nasal canular oxygen or above) 3. Pregnancy women 4. Lactating women 5. Chronic liver disease 6. Meningitis patient 7. Epilepsy who on barbiturate, benzodiazepine or valproic aside as medication 8. Who can&#039,t tolerate to oral feeding 9. Who participate other experimental drugs 10. Who had symptom that might mimicking severe drug adverse reaction (uncontrollable nausea/vomitting, liver function test 3 times UNL or above) 11. Who wish not to participate the study