Have history of severe drug or vaccine allergy Yes (anaphylaxis)? Have ever detected COVID-19 infection? Have history of COVID-19 high risk contact? Did not receive any vaccine within 14 days before the enrollment? Have received blood transfusion, plasma, blood product, blood component, immunoglobulins, antiviral or antibodies within the last 90 days? Being pregnant? Have unstable disease or could not control the symptom? Have history of immunodeficiency or been using immunosuppressant or steroid drugs? Had any of these chronic respiratory tract disease, cardiovascular disease, chronic kidney disease, diabetes, delayed development, and severe neurological conditions? Have any unusual symptoms or medical history that considered unable to participate in the study?

Have history of severe drug or vaccine allergy Yes (anaphylaxis)? Have ever detected COVID-19 infection? Have history of COVID-19 high risk contact? Did not receive any vaccine within 14 days before the enrollment? Have received blood transfusion, plasma, blood product, blood component, immunoglobulins, antiviral or antibodies within the last 90 days? Being pregnant? Have unstable disease or could not control the symptom? Have history of immunodeficiency or been using immunosuppressant or steroid drugs? Had any of these chronic respiratory tract disease, cardiovascular disease, chronic kidney disease, diabetes, delayed development, and severe neurological conditions? Have any unusual symptoms or medical history that considered unable to participate in the study?