inclusion criteria: 1. age at the time of the first dose of vaccine: 18 to 59 years; 2. axillary body temperature is less than 37.3 degree centigrade on the day of enrollment; 3. based on the medical history and relevant physical examination and laboratory examination results (normal or abnormal but no clinical significance), the investigator clinically determined that the patient was in good health; 4. has independent judgment, and participate voluntarily and sign an informed consent form.

inclusion criteria: 1. age at the time of the first dose of vaccine: 18 to 59 years; 2. axillary body temperature is less than 37.3 degree centigrade on the day of enrollment; 3. based on the medical history and relevant physical examination and laboratory examination results (normal or abnormal but no clinical significance), the investigator clinically determined that the patient was in good health; 4. has independent judgment, and participate voluntarily and sign an informed consent form.

inclusion criteria: age at the time of the first dose of vaccine: 18 to 59 years; axillary body temperature is less than 37.3 degree centigrade on the day of enrollment; based on the medical history and relevant physical examination and laboratory examination results (normal or abnormal but no clinical significance), the investigator clinically determined that the patient was in good health; has independent judgment, and participate voluntarily and sign an informed consent form.

inclusion criteria: age at the time of the first dose of vaccine: 18 to 59 years; axillary body temperature is less than 37.3 degree centigrade on the day of enrollment; based on the medical history and relevant physical examination and laboratory examination results (normal or abnormal but no clinical significance), the investigator clinically determined that the patient was in good health; has independent judgment, and participate voluntarily and sign an informed consent form.