inclusion criteria: 1. healthy male or female participants aged 18 years to 50 years at the time of consent 2. ability to read, understand and provide written informed consent 3. willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures 4. healthy participants as established by medical history, laboratory examination, physical examination, vital signs, and ecg during screening and as per the clinical judgment of the investigator 5. body mass index (bmi) 18.0 to 32.0 kg/m2 (inclusive) 6. for woman of childbearing potential (wocbp): agrees to practice true abstinence or agrees to use a highly effective method of contraception consistently from 30 days prior to day 1 until end of the study (day 63). highly effective contraception includes hormonal contraception, placement of intrauterine device (iud) or intrauterine system (ius), or a vasectomized partner (performed at least 6 months prior to her screening) who has been documented to no longer produce sperm. verbal confirmation from the participant through medical interview is acceptable. no contraception requirements for participants in exclusive same-sex relationship. 7. for male participant: must agree to practice true abstinence or use condom if he has a partner of childbearing potential, or must be surgically sterilized (performed at least 6 months prior and documented to no longer produce sperm. verbal confirmation through medical nterview is acceptable). participant to practice abstinence (if applicable) or use condom until end of the study (day 63). no contraception requirements for participants in exclusive same-sex relationship. 8. accessible veins in the forearms for venepuncture and/or intravenous cannulation

inclusion criteria: 1. healthy male or female participants aged 18 years to 50 years at the time of consent 2. ability to read, understand and provide written informed consent 3. willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures 4. healthy participants as established by medical history, laboratory examination, physical examination, vital signs, and ecg during screening and as per the clinical judgment of the investigator 5. body mass index (bmi) 18.0 to 32.0 kg/m2 (inclusive) 6. for woman of childbearing potential (wocbp): agrees to practice true abstinence or agrees to use a highly effective method of contraception consistently from 30 days prior to day 1 until end of the study (day 63). highly effective contraception includes hormonal contraception, placement of intrauterine device (iud) or intrauterine system (ius), or a vasectomized partner (performed at least 6 months prior to her screening) who has been documented to no longer produce sperm. verbal confirmation from the participant through medical interview is acceptable. no contraception requirements for participants in exclusive same-sex relationship. 7. for male participant: must agree to practice true abstinence or use condom if he has a partner of childbearing potential, or must be surgically sterilized (performed at least 6 months prior and documented to no longer produce sperm. verbal confirmation through medical nterview is acceptable). participant to practice abstinence (if applicable) or use condom until end of the study (day 63). no contraception requirements for participants in exclusive same-sex relationship. 8. accessible veins in the forearms for venepuncture and/or intravenous cannulation

inclusion criteria: healthy male or female participants aged 18 years to 50 years at the time of consent ability to read, understand and provide written informed consent willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures healthy participants as established by medical history, laboratory examination, physical examination, vital signs, and ecg during screening and as per the clinical judgment of the investigator body mass index (bmi) 18.0 to 32.0 kg/m2 (inclusive) for woman of childbearing potential (wocbp): agrees to practice true abstinence or agrees to use a highly effective method of contraception consistently from 30 days prior to day 1 until end of the study (day 63). highly effective contraception includes hormonal contraception, placement of intrauterine device (iud) or intrauterine system (ius), or a vasectomized partner (performed at least 6 months prior to her screening) who has been documented to no longer produce sperm. verbal confirmation from the participant through medical interview is acceptable. no contraception requirements for participants in exclusive same-sex relationship. for male participant: must agree to practice true abstinence or use condom if he has a partner of childbearing potential, or must be surgically sterilized (performed at least 6 months prior and documented to no longer produce sperm. verbal confirmation through medical nterview is acceptable). participant to practice abstinence (if applicable) or use condom until end of the study (day 63). no contraception requirements for participants in exclusive same-sex relationship. accessible veins in the forearms for venepuncture and/or intravenous cannulation

inclusion criteria: healthy male or female participants aged 18 years to 50 years at the time of consent ability to read, understand and provide written informed consent willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures healthy participants as established by medical history, laboratory examination, physical examination, vital signs, and ecg during screening and as per the clinical judgment of the investigator body mass index (bmi) 18.0 to 32.0 kg/m2 (inclusive) for woman of childbearing potential (wocbp): agrees to practice true abstinence or agrees to use a highly effective method of contraception consistently from 30 days prior to day 1 until end of the study (day 63). highly effective contraception includes hormonal contraception, placement of intrauterine device (iud) or intrauterine system (ius), or a vasectomized partner (performed at least 6 months prior to her screening) who has been documented to no longer produce sperm. verbal confirmation from the participant through medical interview is acceptable. no contraception requirements for participants in exclusive same-sex relationship. for male participant: must agree to practice true abstinence or use condom if he has a partner of childbearing potential, or must be surgically sterilized (performed at least 6 months prior and documented to no longer produce sperm. verbal confirmation through medical nterview is acceptable). participant to practice abstinence (if applicable) or use condom until end of the study (day 63). no contraception requirements for participants in exclusive same-sex relationship. accessible veins in the forearms for venepuncture and/or intravenous cannulation