inclusion criteria: * hospitalized 18 years old or older patient with covid-19 disease, confirmed by a molecular test or a serologic test, along with a typical covid-19 clinical presentation. * severe or critical disease caused by covid-19 severe disease is defined as 2 or more of the following criteria: * respiratory frequency \>22 * o2 saturation ≤93% * pao2 50mmhg * pao2/fio2 \<300 * or critical disease with one or more of the following criteria: * respiratory insufficiency with requirement of mechanical ventilation within the last 72hours * shock * inform consent signed by patient or direct family member.

inclusion criteria: * hospitalized 18 years old or older patient with covid-19 disease, confirmed by a molecular test or a serologic test, along with a typical covid-19 clinical presentation. * severe or critical disease caused by covid-19 severe disease is defined as 2 or more of the following criteria: * respiratory frequency \>22 * o2 saturation ≤93% * pao2 50mmhg * pao2/fio2 \<300 * or critical disease with one or more of the following criteria: * respiratory insufficiency with requirement of mechanical ventilation within the last 72hours * shock * inform consent signed by patient or direct family member.

inclusion criteria: - hospitalized 18 years old or older patient with covid-19 disease, confirmed by a molecular test or a serologic test, along with a typical covid-19 clinical presentation. - severe or critical disease caused by covid-19 severe disease is defined as 2 or more of the following criteria: - respiratory frequency >22 - o2 saturation ≤93% - pao2 50mmhg - pao2/fio2 <300 - or critical disease with one or more of the following criteria: - respiratory insufficiency with requirement of mechanical ventilation within the last 72hours - shock - inform consent signed by patient or direct family member.

inclusion criteria: - hospitalized 18 years old or older patient with covid-19 disease, confirmed by a molecular test or a serologic test, along with a typical covid-19 clinical presentation. - severe or critical disease caused by covid-19 severe disease is defined as 2 or more of the following criteria: - respiratory frequency >22 - o2 saturation ≤93% - pao2 50mmhg - pao2/fio2 <300 - or critical disease with one or more of the following criteria: - respiratory insufficiency with requirement of mechanical ventilation within the last 72hours - shock - inform consent signed by patient or direct family member.