* contraindication for transfusion (history of trali or taco, history of anaphylaxis to blood components * multiorgan failure, defined by a sofa score of \>5 * hemodynamically unstable, with mean arterial pressure \<60 mmhg, refractory to vasopressors use * uncontrolled concomitant infection * disseminated intravascular coagulation * myocardial infarction * acute coronary disease * patient on dialysis * intracranial bleeding active within the last 7 days * pregnancy

* contraindication for transfusion (history of trali or taco, history of anaphylaxis to blood components * multiorgan failure, defined by a sofa score of \>5 * hemodynamically unstable, with mean arterial pressure \<60 mmhg, refractory to vasopressors use * uncontrolled concomitant infection * disseminated intravascular coagulation * myocardial infarction * acute coronary disease * patient on dialysis * intracranial bleeding active within the last 7 days * pregnancy

- contraindication for transfusion (history of trali or taco, history of anaphylaxis to blood components - multiorgan failure, defined by a sofa score of >5 - hemodynamically unstable, with mean arterial pressure <60 mmhg, refractory to vasopressors use - uncontrolled concomitant infection - disseminated intravascular coagulation - myocardial infarction - acute coronary disease - patient on dialysis - intracranial bleeding active within the last 7 days - pregnancy

- contraindication for transfusion (history of trali or taco, history of anaphylaxis to blood components - multiorgan failure, defined by a sofa score of >5 - hemodynamically unstable, with mean arterial pressure <60 mmhg, refractory to vasopressors use - uncontrolled concomitant infection - disseminated intravascular coagulation - myocardial infarction - acute coronary disease - patient on dialysis - intracranial bleeding active within the last 7 days - pregnancy