inclusion criteria: 1. subjects of both sexes aged 18 to 79 years of age 2. sars-cov-2 infection confirmed by pcr for virus detection 3. patients with moderate or severe disease by nih definition, which requires hospitalization. 4. acceptance to participate in the study by the signature of the informed consent by a subject or their relative, if applicable 5. be within 10 days of the onset of symptoms at the time of the screening visit according to a case definition from the national ministry of health 6. female patients of child-bearing age with negative pregnancy test

inclusion criteria: 1. subjects of both sexes aged 18 to 79 years of age 2. sars-cov-2 infection confirmed by pcr for virus detection 3. patients with moderate or severe disease by nih definition, which requires hospitalization. 4. acceptance to participate in the study by the signature of the informed consent by a subject or their relative, if applicable 5. be within 10 days of the onset of symptoms at the time of the screening visit according to a case definition from the national ministry of health 6. female patients of child-bearing age with negative pregnancy test

inclusion criteria: subjects of both sexes aged 18 to 79 years of age sars-cov-2 infection confirmed by pcr for virus detection patients with moderate or severe disease by nih definition, which requires hospitalization. acceptance to participate in the study by the signature of the informed consent by a subject or their relative, if applicable be within 10 days of the onset of symptoms at the time of the screening visit according to a case definition from the national ministry of health female patients of child-bearing age with negative pregnancy test

inclusion criteria: subjects of both sexes aged 18 to 79 years of age sars-cov-2 infection confirmed by pcr for virus detection patients with moderate or severe disease by nih definition, which requires hospitalization. acceptance to participate in the study by the signature of the informed consent by a subject or their relative, if applicable be within 10 days of the onset of symptoms at the time of the screening visit according to a case definition from the national ministry of health female patients of child-bearing age with negative pregnancy test

inclusion criteria: 1. subjects of both sexes aged 18 to 79 years of age 2. sars-cov-2 infection confirmed by pcr for virus detection 3. patients with moderate or severe disease by nih definition, which requires hospitalization. 4. acceptance to participate in the study by the signature of the informed consent by a subject or their relative, if applicable 5. be within 10 days of the onset of symptoms at the time of the screening visit according to a case definition from the national ministry of health 6. female patients of child-bearing age with negative pregnancy test

inclusion criteria: 1. subjects of both sexes aged 18 to 79 years of age 2. sars-cov-2 infection confirmed by pcr for virus detection 3. patients with moderate or severe disease by nih definition, which requires hospitalization. 4. acceptance to participate in the study by the signature of the informed consent by a subject or their relative, if applicable 5. be within 10 days of the onset of symptoms at the time of the screening visit according to a case definition from the national ministry of health 6. female patients of child-bearing age with negative pregnancy test