inclusion criteria: 1. age \>18 at the time of screening. 2. participant or legally authorized representative (lar) must be able to understand and provide informed consent. 3. hospitalized with coronavirus disease (covid-19) confirmed by polymerase chain reaction (pcr) assay from any specimen (eg, respiratory, blood, urine, stool, other bodily fluid) within the prior 72 hours. 4. c-reactive protein (crp) \> 3.5 mg/dl 5. evidence of pulmonary involvement with at least 2 of the following: 1. oxygen saturation at rest in ambient air with peripheral capillary oxygen saturation (spo2) ≤ 94% 2. tachypnea with resting respiration rate \> 25 breaths/minute 3. partial pressure of oxygen (pao2)/initial fraction of inspired oxygen (fio2) ≤ 300 mmhg 4. chest imaging (radiograph, ct, or ultrasound) with abnormalities consistent covid-19 pneumonia

inclusion criteria: 1. age \>18 at the time of screening. 2. participant or legally authorized representative (lar) must be able to understand and provide informed consent. 3. hospitalized with coronavirus disease (covid-19) confirmed by polymerase chain reaction (pcr) assay from any specimen (eg, respiratory, blood, urine, stool, other bodily fluid) within the prior 72 hours. 4. c-reactive protein (crp) \> 3.5 mg/dl 5. evidence of pulmonary involvement with at least 2 of the following: 1. oxygen saturation at rest in ambient air with peripheral capillary oxygen saturation (spo2) ≤ 94% 2. tachypnea with resting respiration rate \> 25 breaths/minute 3. partial pressure of oxygen (pao2)/initial fraction of inspired oxygen (fio2) ≤ 300 mmhg 4. chest imaging (radiograph, ct, or ultrasound) with abnormalities consistent covid-19 pneumonia

inclusion criteria: age >18 at the time of screening. participant or legally authorized representative (lar) must be able to understand and provide informed consent. hospitalized with coronavirus disease (covid-19) confirmed by polymerase chain reaction (pcr) assay from any specimen (eg, respiratory, blood, urine, stool, other bodily fluid) within the prior 72 hours. c-reactive protein (crp) > 3.5 mg/dl evidence of pulmonary involvement with at least 2 of the following: oxygen saturation at rest in ambient air with peripheral capillary oxygen saturation (spo2) ≤ 94% tachypnea with resting respiration rate > 25 breaths/minute partial pressure of oxygen (pao2)/initial fraction of inspired oxygen (fio2) ≤ 300 mmhg chest imaging (radiograph, ct, or ultrasound) with abnormalities consistent covid-19 pneumonia

inclusion criteria: age >18 at the time of screening. participant or legally authorized representative (lar) must be able to understand and provide informed consent. hospitalized with coronavirus disease (covid-19) confirmed by polymerase chain reaction (pcr) assay from any specimen (eg, respiratory, blood, urine, stool, other bodily fluid) within the prior 72 hours. c-reactive protein (crp) > 3.5 mg/dl evidence of pulmonary involvement with at least 2 of the following: oxygen saturation at rest in ambient air with peripheral capillary oxygen saturation (spo2) ≤ 94% tachypnea with resting respiration rate > 25 breaths/minute partial pressure of oxygen (pao2)/initial fraction of inspired oxygen (fio2) ≤ 300 mmhg chest imaging (radiograph, ct, or ultrasound) with abnormalities consistent covid-19 pneumonia

inclusion criteria: 1. age >18 at the time of screening. 2. participant or legally authorized representative (lar) must be able to understand and provide informed consent. 3. hospitalized with coronavirus disease (covid-19) confirmed by polymerase chain reaction (pcr) assay from any specimen (eg, respiratory, blood, urine, stool, other bodily fluid) within the prior 72 hours. 4. c-reactive protein (crp) > 3.5 mg/dl 5. evidence of pulmonary involvement with at least 2 of the following: 1. oxygen saturation at rest in ambient air with peripheral capillary oxygen saturation (spo2) ≤ 94% 2. tachypnea with resting respiration rate > 25 breaths/minute 3. partial pressure of oxygen (pao2)/initial fraction of inspired oxygen (fio2) ≤ 300 mmhg 4. chest imaging (radiograph, ct, or ultrasound) with abnormalities consistent covid-19 pneumonia

inclusion criteria: 1. age >18 at the time of screening. 2. participant or legally authorized representative (lar) must be able to understand and provide informed consent. 3. hospitalized with coronavirus disease (covid-19) confirmed by polymerase chain reaction (pcr) assay from any specimen (eg, respiratory, blood, urine, stool, other bodily fluid) within the prior 72 hours. 4. c-reactive protein (crp) > 3.5 mg/dl 5. evidence of pulmonary involvement with at least 2 of the following: 1. oxygen saturation at rest in ambient air with peripheral capillary oxygen saturation (spo2) ≤ 94% 2. tachypnea with resting respiration rate > 25 breaths/minute 3. partial pressure of oxygen (pao2)/initial fraction of inspired oxygen (fio2) ≤ 300 mmhg 4. chest imaging (radiograph, ct, or ultrasound) with abnormalities consistent covid-19 pneumonia