inclusion criteria: 1. laboratory-confirmed covid-19 infection as determined by polymerase chain reaction (pcr) 2. hospitalized patients that meets one of the following conditions: 1. radiographic infiltrates by imaging (chest x-ray, ct scan, etc.); or 2. at rest, blood oxygen saturation ≤ 94%; or 3. require supplemental oxygen; or 4. requiring non-invasive ventilation; or 5. requiring invasive mechanical ventilation for up to 2 days. 3. age ≥ 18 years. enrollment of patients ≥70 years of age may be limited (e.g., comprise no more than 10% of all randomized patients), pending safety review by the dsmb and executive committee 4. participant or legally authorized representative is willing to give informed consent

inclusion criteria: 1. laboratory-confirmed covid-19 infection as determined by polymerase chain reaction (pcr) 2. hospitalized patients that meets one of the following conditions: 1. radiographic infiltrates by imaging (chest x-ray, ct scan, etc.); or 2. at rest, blood oxygen saturation ≤ 94%; or 3. require supplemental oxygen; or 4. requiring non-invasive ventilation; or 5. requiring invasive mechanical ventilation for up to 2 days. 3. age ≥ 18 years. enrollment of patients ≥70 years of age may be limited (e.g., comprise no more than 10% of all randomized patients), pending safety review by the dsmb and executive committee 4. participant or legally authorized representative is willing to give informed consent

inclusion criteria: laboratory-confirmed covid-19 infection as determined by polymerase chain reaction (pcr) hospitalized patients that meets one of the following conditions: radiographic infiltrates by imaging (chest x-ray, ct scan, etc.); or at rest, blood oxygen saturation ≤ 94%; or require supplemental oxygen; or requiring non-invasive ventilation; or requiring invasive mechanical ventilation for up to 2 days. age ≥ 18 years. enrollment of patients ≥70 years of age may be limited (e.g., comprise no more than 10% of all randomized patients), pending safety review by the dsmb and executive committee participant or legally authorized representative is willing to give informed consent

inclusion criteria: laboratory-confirmed covid-19 infection as determined by polymerase chain reaction (pcr) hospitalized patients that meets one of the following conditions: radiographic infiltrates by imaging (chest x-ray, ct scan, etc.); or at rest, blood oxygen saturation ≤ 94%; or require supplemental oxygen; or requiring non-invasive ventilation; or requiring invasive mechanical ventilation for up to 2 days. age ≥ 18 years. enrollment of patients ≥70 years of age may be limited (e.g., comprise no more than 10% of all randomized patients), pending safety review by the dsmb and executive committee participant or legally authorized representative is willing to give informed consent

inclusion criteria: 1. laboratory-confirmed covid-19 infection as determined by polymerase chain reaction (pcr) 2. hospitalized patients that meets one of the following conditions: 1. radiographic infiltrates by imaging (chest x-ray, ct scan, etc.); or 2. at rest, blood oxygen saturation ≤ 94%; or 3. require supplemental oxygen; or 4. requiring non-invasive ventilation; or 5. requiring invasive mechanical ventilation for up to 2 days. 3. age ≥ 18 years. enrollment of patients ≥70 years of age may be limited (e.g., comprise no more than 10% of all randomized patients), pending safety review by the dsmb and executive committee 4. participant or legally authorized representative is willing to give informed consent

inclusion criteria: 1. laboratory-confirmed covid-19 infection as determined by polymerase chain reaction (pcr) 2. hospitalized patients that meets one of the following conditions: 1. radiographic infiltrates by imaging (chest x-ray, ct scan, etc.); or 2. at rest, blood oxygen saturation ≤ 94%; or 3. require supplemental oxygen; or 4. requiring non-invasive ventilation; or 5. requiring invasive mechanical ventilation for up to 2 days. 3. age ≥ 18 years. enrollment of patients ≥70 years of age may be limited (e.g., comprise no more than 10% of all randomized patients), pending safety review by the dsmb and executive committee 4. participant or legally authorized representative is willing to give informed consent