1. Pregnancy or breastfeeding 2. Severe illness: including pneumonia with the following condition 2.1 Respiratory rates more than 24 per minute 2.2 Oxygen saturation less than 95% 3. Need for oxygen therapy 4. chronic oxygen therapy with the need to increase oxygen flow from the other pulmonary disease except from COVID-19 5. Patient who need hospitalization 6. Chest X-ray showed more than 50% bilateral infiltration, or chest CT showed multifocal consolidation, crazy paving pattern, ARDS 7. Intake the other anti-SARS-CoV-2 therapy more than 24 hours 8. Child-Pugh score C or end-stage-renal disease without dialysis or hemodialysis less than two times/week 9. Advanced stage cancer or palliative treatment (with life expectancy less than three months) 10. Bed-ridden and need hospitalization 11. Received neutralizing monoclonal antibody or plasma in 60 days 12. severe allergic reaction to favipiravir or sotrovimab 13. History of severe transfusion reaction

1. Pregnancy or breastfeeding 2. Severe illness: including pneumonia with the following condition 2.1 Respiratory rates more than 24 per minute 2.2 Oxygen saturation less than 95% 3. Need for oxygen therapy 4. chronic oxygen therapy with the need to increase oxygen flow from the other pulmonary disease except from COVID-19 5. Patient who need hospitalization 6. Chest X-ray showed more than 50% bilateral infiltration, or chest CT showed multifocal consolidation, crazy paving pattern, ARDS 7. Intake the other anti-SARS-CoV-2 therapy more than 24 hours 8. Child-Pugh score C or end-stage-renal disease without dialysis or hemodialysis less than two times/week 9. Advanced stage cancer or palliative treatment (with life expectancy less than three months) 10. Bed-ridden and need hospitalization 11. Received neutralizing monoclonal antibody or plasma in 60 days 12. severe allergic reaction to favipiravir or sotrovimab 13. History of severe transfusion reaction