1. Confirmed cases of or asymptomatic COVID-19 infection or have a history of positive nucleic acid test of SARS-COV-2 2. Fever caused by any reason (such as cold, local inflammation, tumor, rheumatic immune disease, etc.) or armpit temperature 37.3 Celsius or more on the day of enrollment 3. Past severe allergic history to any vaccine, or active ingredients of the test vaccine, any inactive ingredients, and substances used in the production process, including aluminum preparations, such as acute allergic reaction, anaphylactic shock, allergic laryngeal edema, allergic purpura, thrombocytopenic purpura, dyspnea, angioneurotic edema. 4. History of respiratory tract infection within 14 days before enrollment. 5. Lactating women or pregnant women (including women with positive urine pregnancy test of childbearing age. 6. Uncontrolled comorbidity disease (adjust dose of the medication within 3 months). 7. Participants with malignancy comorbidity disease and currently received chemotherapy. 8. Currently received high dose steroid (20 mg per day of more of prednisolone or prednisolone equivalent) 9. Received immunosuppressive agents. 10. Age more than 60 years old. 11. Malnutrition status (Define as BMI less than 17 kg/m2)

1. Confirmed cases of or asymptomatic COVID-19 infection or have a history of positive nucleic acid test of SARS-COV-2 2. Fever caused by any reason (such as cold, local inflammation, tumor, rheumatic immune disease, etc.) or armpit temperature 37.3 Celsius or more on the day of enrollment 3. Past severe allergic history to any vaccine, or active ingredients of the test vaccine, any inactive ingredients, and substances used in the production process, including aluminum preparations, such as acute allergic reaction, anaphylactic shock, allergic laryngeal edema, allergic purpura, thrombocytopenic purpura, dyspnea, angioneurotic edema. 4. History of respiratory tract infection within 14 days before enrollment. 5. Lactating women or pregnant women (including women with positive urine pregnancy test of childbearing age. 6. Uncontrolled comorbidity disease (adjust dose of the medication within 3 months). 7. Participants with malignancy comorbidity disease and currently received chemotherapy. 8. Currently received high dose steroid (20 mg per day of more of prednisolone or prednisolone equivalent) 9. Received immunosuppressive agents. 10. Age more than 60 years old. 11. Malnutrition status (Define as BMI less than 17 kg/m2)