1. Any confirmed or suspected immunosuppressive or immunodeficient state. 2. No history of COVID infection. 3. Pregnancy 4. History of vaccination with other vaccines within 2 weeks prior to enrollment. 5. Having a plan to receive any vaccines within two weeks after enrolment 6. acute febrile illness with body temperature higher than 38 degrees Celsius on the day of enrolment, or any other acute illness 7. history of anaphylaxis to other vaccines 8. Uncontrolled of personal medical illness, i.e., heart disease, neurological condition. 9. Bleeding tendency, abnormality of platelet functions, or ongoing use of antithrombotic prophylaxis

1. Any confirmed or suspected immunosuppressive or immunodeficient state. 2. No history of COVID infection. 3. Pregnancy 4. History of vaccination with other vaccines within 2 weeks prior to enrollment. 5. Having a plan to receive any vaccines within two weeks after enrolment 6. acute febrile illness with body temperature higher than 38 degrees Celsius on the day of enrolment, or any other acute illness 7. history of anaphylaxis to other vaccines 8. Uncontrolled of personal medical illness, i.e., heart disease, neurological condition. 9. Bleeding tendency, abnormality of platelet functions, or ongoing use of antithrombotic prophylaxis