* contraindications to unfractionated heparin or lmwh * recent (\<48 hours) or planned spinal or epidural anesthesia or puncture, pci or thrombolytic therapy within the preceding 24 hours * increased risk for bleeding complications * pregnant women * severe renal impairment (gfr \< 30 ml/min) * receiving any antiplatelet therapy (with the exception of low dose (≤100mg) aspirin) or anticoagulant therapy (e.g. vka, doac) * patients participating in an interventional study that is outside the purview of tri sponsored studies.

* contraindications to unfractionated heparin or lmwh * recent (\<48 hours) or planned spinal or epidural anesthesia or puncture, pci or thrombolytic therapy within the preceding 24 hours * increased risk for bleeding complications * pregnant women * severe renal impairment (gfr \< 30 ml/min) * receiving any antiplatelet therapy (with the exception of low dose (≤100mg) aspirin) or anticoagulant therapy (e.g. vka, doac) * patients participating in an interventional study that is outside the purview of tri sponsored studies.

- contraindications to unfractionated heparin or lmwh - recent (<48 hours) or planned spinal or epidural anesthesia or puncture, pci or thrombolytic therapy within the preceding 24 hours - increased risk for bleeding complications - pregnant women - severe renal impairment (gfr < 30 ml/min) - receiving any antiplatelet therapy (with the exception of low dose (≤100mg) aspirin) or anticoagulant therapy (e.g. vka, doac) - patients participating in an interventional study that is outside the purview of tri sponsored studies.

- contraindications to unfractionated heparin or lmwh - recent (<48 hours) or planned spinal or epidural anesthesia or puncture, pci or thrombolytic therapy within the preceding 24 hours - increased risk for bleeding complications - pregnant women - severe renal impairment (gfr < 30 ml/min) - receiving any antiplatelet therapy (with the exception of low dose (≤100mg) aspirin) or anticoagulant therapy (e.g. vka, doac) - patients participating in an interventional study that is outside the purview of tri sponsored studies.