Created at Source Raw Value Validated value
April 8, 2022, 3:30 p.m. oms

[{"arm_notes": "", "treatment_id": null, "treatment_name": "Intervention1: nebulised Heparin: Heparin sodium 25;000 Units in 5 mL manufactured by Pfizer Australia Pty Ltd (Sydney; Australia) or an equivalent unfractionated heparin by another approved manufacturer will be used. The medication will be stored in a secure area and dispensed by pharmacists and physicians under the supervision of investigators.Heparin sodium will be administered as a nebulised aerosol dose of 25;000 IU heparin three times a day (TDS) via an Aerogen Solo (Aerogen; Ireland) vibrating mesh aerosol drug nebulizer. It has been estimated that 20% of the heparin dose is administered to the lungs by this method using Anderson cascade impactor (data on file). Nebulised Heparin Sodium 25;000 IU will be delivered using air or oxygen three times a day (TDS); daily for up to 21 days; or until the patient has no respiratory symptoms. The mode of delivery (via mask; mouthpiece or spacer) will be chosen by the clinical team depending on the patient\u00e2??s needs for oxygen and ventilatory support. Control Intervention1: Standard of Care for COVID Treatment: Participants assigned to \u00e2??standard care\u00e2?? will receive the standard care required as determined by the treating team and will not be treated with nebulised heparin.", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}, {"arm_notes": "", "treatment_id": null, "treatment_name": "Intervention1: nebulised Heparin: Heparin sodium 25;000 Units in 5 mL manufactured by Pfizer Australia Pty Ltd (Sydney; Australia) or an equivalent unfractionated heparin by another approved manufacturer will be used. The medication will be stored in a secure area and dispensed by pharmacists and physicians under the supervision of investigators.Heparin sodium will be administered as a nebulised aerosol dose of 25;000 IU heparin three times a day (TDS) via an Aerogen Solo (Aerogen; Ireland) vibrating mesh aerosol drug nebulizer. It has been estimated that 20% of the heparin dose is administered to the lungs by this method using Anderson cascade impactor (data on file). Nebulised Heparin Sodium 25;000 IU will be delivered using air or oxygen three times a day (TDS); daily for up to 21 days; or until the patient has no respiratory symptoms. The mode of delivery (via mask; mouthpiece or spacer) will be chosen by the clinical team depending on the patient\u00e2??s needs for oxygen and ventilatory support.", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}, {"arm_notes": "", "treatment_id": null, "treatment_name": "Control Intervention1: Standard of Care for COVID Treatment: Participants assigned to \u00e2??standard care\u00e2?? will receive the standard care required as determined by the treating team and will not be treated with nebulised heparin.", "treatment_type": "TODO", "pharmacological_treatment": "TODO"}]

[{"arm_notes": "", "treatment_id": 873, "treatment_name": "Nebulised unfractionated heparin (ufh)", "treatment_type": "Coagulation modifiers", "pharmacological_treatment": "Pharmacological treatment"}, {"arm_notes": "", "treatment_id": 2188, "treatment_name": "Standard of care", "treatment_type": "Standard of care", "pharmacological_treatment": "Standard of care"}]