* patients with severe comorbid factors such as: uncontrolled congestive heart disease, renal insufficiency, coronary heart disease, chronic liver disease, diabetes mellitus with complications, uncontrolled hypertension or crisis hypertension, immunocompromised, cns disorders (such as stroke, epilepsy, alzheimer's, meningitis) , cancer, hiv, aids. * subjects who are pregnant or breastfeeding. * subjects who cannot be included in the study according to consideration of the researcher. * subjects who are in the process of taking other drug clinical trials. * subjects with a history of allergy to the components of the test drug.

* patients with severe comorbid factors such as: uncontrolled congestive heart disease, renal insufficiency, coronary heart disease, chronic liver disease, diabetes mellitus with complications, uncontrolled hypertension or crisis hypertension, immunocompromised, cns disorders (such as stroke, epilepsy, alzheimer's, meningitis) , cancer, hiv, aids. * subjects who are pregnant or breastfeeding. * subjects who cannot be included in the study according to consideration of the researcher. * subjects who are in the process of taking other drug clinical trials. * subjects with a history of allergy to the components of the test drug.

patients with severe comorbid factors such as: uncontrolled congestive heart disease, renal insufficiency, coronary heart disease, chronic liver disease, diabetes mellitus with complications, uncontrolled hypertension or crisis hypertension, immunocompromised, cns disorders (such as stroke, epilepsy, alzheimer's, meningitis) , cancer, hiv, aids. subjects who are pregnant or breastfeeding. subjects who cannot be included in the study according to consideration of the researcher. subjects who are in the process of taking other drug clinical trials. subjects with a history of allergy to the components of the test drug.

patients with severe comorbid factors such as: uncontrolled congestive heart disease, renal insufficiency, coronary heart disease, chronic liver disease, diabetes mellitus with complications, uncontrolled hypertension or crisis hypertension, immunocompromised, cns disorders (such as stroke, epilepsy, alzheimer's, meningitis) , cancer, hiv, aids. subjects who are pregnant or breastfeeding. subjects who cannot be included in the study according to consideration of the researcher. subjects who are in the process of taking other drug clinical trials. subjects with a history of allergy to the components of the test drug.