inclusion criteria: * male, female or transgender, ≥ 18 years old at day 0. * provide inform consent form * participant who has: * 3 doses of mrna vaccines * 2 doses of mrna vaccines and previous covid-19 infection * 2 doses of coronavac and 1 comirnaty, or, 1 coronavac and 2 comirnaty * participant who has: * hiv infection with cd4 tcells counts \<400 * primary antibody deficiency disorders * kidney disease on dialysis * kidney transplant at least \>1 year * auto immune disease (aid) in treatment with rituximab * for a female of childbearing potential, to have a negative pregnancy test at day 0 * use of any of these contraception: * female: hormonal contraception, intrauterine device, vasectomized partner, sexual abstinence, condom. * male: vasectomized participant, sexual abstinence, condom.

inclusion criteria: * male, female or transgender, ≥ 18 years old at day 0. * provide inform consent form * participant who has: * 3 doses of mrna vaccines * 2 doses of mrna vaccines and previous covid-19 infection * 2 doses of coronavac and 1 comirnaty, or, 1 coronavac and 2 comirnaty * participant who has: * hiv infection with cd4 tcells counts \<400 * primary antibody deficiency disorders * kidney disease on dialysis * kidney transplant at least \>1 year * auto immune disease (aid) in treatment with rituximab * for a female of childbearing potential, to have a negative pregnancy test at day 0 * use of any of these contraception: * female: hormonal contraception, intrauterine device, vasectomized partner, sexual abstinence, condom. * male: vasectomized participant, sexual abstinence, condom.

inclusion criteria: male, female or transgender, ≥ 18 years old at day 0. provide inform consent form participant who has: 3 doses of mrna vaccines 2 doses of mrna vaccines and previous covid-19 infection 2 doses of coronavac and 1 comirnaty, or, 1 coronavac and 2 comirnaty participant who has: hiv infection with cd4 tcells counts <400 primary antibody deficiency disorders kidney disease on dialysis kidney transplant at least >1 year auto immune disease (aid) in treatment with rituximab for a female of childbearing potential, to have a negative pregnancy test at day 0 use of any of these contraception: female: hormonal contraception, intrauterine device, vasectomized partner, sexual abstinence, condom. male: vasectomized participant, sexual abstinence, condom.

inclusion criteria: male, female or transgender, ≥ 18 years old at day 0. provide inform consent form participant who has: 3 doses of mrna vaccines 2 doses of mrna vaccines and previous covid-19 infection 2 doses of coronavac and 1 comirnaty, or, 1 coronavac and 2 comirnaty participant who has: hiv infection with cd4 tcells counts <400 primary antibody deficiency disorders kidney disease on dialysis kidney transplant at least >1 year auto immune disease (aid) in treatment with rituximab for a female of childbearing potential, to have a negative pregnancy test at day 0 use of any of these contraception: female: hormonal contraception, intrauterine device, vasectomized partner, sexual abstinence, condom. male: vasectomized participant, sexual abstinence, condom.

inclusion criteria: male, female or transgender, ≥ 18 years old at day 0. provide inform consent form participant who has: 3 doses of mrna vaccines 2 doses of mrna vaccines and previous covid-19 infection 2 doses of coronavac and 1 comirnaty, or, 1 coronavac and 2 comirnaty participant who has: hiv infection with cd4 tcells counts <400 primary antibody deficiency disorders kidney disease on dialysis kidney transplant at least >1 year auto immune disease (aid) for a female of childbearing potential, to have a negative pregnancy test at day 0 use of any of these contraception: female: hormonal contraception, intrauterine device, vasectomized partner, sexual abstinence, condom. male: vasectomized participant, sexual abstinence, condom.

inclusion criteria: male, female or transgender, ≥ 18 years old at day 0. provide inform consent form participant who has: 3 doses of mrna vaccines 2 doses of mrna vaccines and previous covid-19 infection 2 doses of coronavac and 1 comirnaty, or, 1 coronavac and 2 comirnaty participant who has: hiv infection with cd4 tcells counts <400 primary antibody deficiency disorders kidney disease on dialysis kidney transplant at least >1 year auto immune disease (aid) for a female of childbearing potential, to have a negative pregnancy test at day 0 use of any of these contraception: female: hormonal contraception, intrauterine device, vasectomized partner, sexual abstinence, condom. male: vasectomized participant, sexual abstinence, condom.