* history of anaphylaxis to any prior vaccine * participants has received or plans to receive live attenuated vaccines, other not live vaccines, or vaxzevria or janssen vaccines. * pregnant or breast-feeding at day 0. * a confirmed covid-19 diagnose \<90 days prior to vaccination day 0. * a clinically significant acute illness or fever at screening or 48h before day 0. * participant had a surgery requiring hospitalisation and has not received the hospital discharge. * participant has an ongoing severe and non-stable psychiatric condition * participant has a problematic or risky use of substances including alcohol * participant has a bleeding disorder that contraindicates intramuscular injection * participant suffering from post-acute covid-19 syndrome / long covid * participant received any immunotherapy to prevent/treat covid-19 in the last 90 days * participant is already participating in another research involving drug, biologics or device * participant has donated ≥450 ml of blood products within 12 weeks before screening * participant has any medical condition and/or finding that in the investigator opinion might increase participant risk, interfere with the study or impair interpretation of study data.

* history of anaphylaxis to any prior vaccine * participants has received or plans to receive live attenuated vaccines, other not live vaccines, or vaxzevria or janssen vaccines. * pregnant or breast-feeding at day 0. * a confirmed covid-19 diagnose \<90 days prior to vaccination day 0. * a clinically significant acute illness or fever at screening or 48h before day 0. * participant had a surgery requiring hospitalisation and has not received the hospital discharge. * participant has an ongoing severe and non-stable psychiatric condition * participant has a problematic or risky use of substances including alcohol * participant has a bleeding disorder that contraindicates intramuscular injection * participant suffering from post-acute covid-19 syndrome / long covid * participant received any immunotherapy to prevent/treat covid-19 in the last 90 days * participant is already participating in another research involving drug, biologics or device * participant has donated ≥450 ml of blood products within 12 weeks before screening * participant has any medical condition and/or finding that in the investigator opinion might increase participant risk, interfere with the study or impair interpretation of study data.

history of anaphylaxis to any prior vaccine participants has received or plans to receive live attenuated vaccines, other not live vaccines, or vaxzevria or janssen vaccines. pregnant or breast-feeding at day 0. a confirmed covid-19 diagnose <90 days prior to vaccination day 0. a clinically significant acute illness or fever at screening or 48h before day 0. participant had a surgery requiring hospitalisation and has not received the hospital discharge. participant has an ongoing severe and non-stable psychiatric condition participant has a problematic or risky use of substances including alcohol participant has a bleeding disorder that contraindicates intramuscular injection participant suffering from post-acute covid-19 syndrome / long covid participant received any immunotherapy to prevent/treat covid-19 in the last 90 days participant is already participating in another research involving drug, biologics or device participant has donated ≥450 ml of blood products within 12 weeks before screening participant has any medical condition and/or finding that in the investigator opinion might increase participant risk, interfere with the study or impair interpretation of study data.

history of anaphylaxis to any prior vaccine participants has received or plans to receive live attenuated vaccines, other not live vaccines, or vaxzevria or janssen vaccines. pregnant or breast-feeding at day 0. a confirmed covid-19 diagnose <90 days prior to vaccination day 0. a clinically significant acute illness or fever at screening or 48h before day 0. participant had a surgery requiring hospitalisation and has not received the hospital discharge. participant has an ongoing severe and non-stable psychiatric condition participant has a problematic or risky use of substances including alcohol participant has a bleeding disorder that contraindicates intramuscular injection participant suffering from post-acute covid-19 syndrome / long covid participant received any immunotherapy to prevent/treat covid-19 in the last 90 days participant is already participating in another research involving drug, biologics or device participant has donated ≥450 ml of blood products within 12 weeks before screening participant has any medical condition and/or finding that in the investigator opinion might increase participant risk, interfere with the study or impair interpretation of study data.

history of anaphylaxis to any prior vaccine participants has received or plans to receive live attenuated vaccines, other not live vaccines, or vaxzevria or janssen vaccines. pregnant or breast-feeding at day 0. a confirmed covid-19 diagnose <90 days prior to vaccination day 0. a clinically significant acute illness or fever at screening or 48h before day 0. participant had a surgery requiring hospitalisation and has not received the hospital discharge. participant has an ongoing severe and non-stable psychiatric condition participant has a problematic or use risk of substances including alcohol participant has a bleeding disorder that contraindicates intramuscular injection participant suffering from post-acute covid-19 syndrome / long covid participant received any immunotherapy to prevent/treat covid-19 in the last 90 days participant is already participating in another research involving drug, biologics or device participant has donated ≥450 ml of blood products within 12 weeks before screening participant has any medical condition and/or finding that in the investigator opinion might increase participant risk, interfere with the study or impair interpretation os study data.

history of anaphylaxis to any prior vaccine participants has received or plans to receive live attenuated vaccines, other not live vaccines, or vaxzevria or janssen vaccines. pregnant or breast-feeding at day 0. a confirmed covid-19 diagnose <90 days prior to vaccination day 0. a clinically significant acute illness or fever at screening or 48h before day 0. participant had a surgery requiring hospitalisation and has not received the hospital discharge. participant has an ongoing severe and non-stable psychiatric condition participant has a problematic or use risk of substances including alcohol participant has a bleeding disorder that contraindicates intramuscular injection participant suffering from post-acute covid-19 syndrome / long covid participant received any immunotherapy to prevent/treat covid-19 in the last 90 days participant is already participating in another research involving drug, biologics or device participant has donated ≥450 ml of blood products within 12 weeks before screening participant has any medical condition and/or finding that in the investigator opinion might increase participant risk, interfere with the study or impair interpretation os study data.