inclusion criteria: 1. men or women with age ≥18 and ≤85 years. 2. in case of women of childbearing potential (wocbp), they should confirm menstrual period and a negative highly sensitive urine or serum pregnancy test to be included. 3. laboratory-confirmed sars-cov-2 infection. 4. informed consent obtained . 5. hypoxia (spo2\<95%). 6. documented lung opacities/infiltrates. 7. confirmed hyperinflammation.

inclusion criteria: 1. men or women with age ≥18 and ≤85 years. 2. in case of women of childbearing potential (wocbp), they should confirm menstrual period and a negative highly sensitive urine or serum pregnancy test to be included. 3. laboratory-confirmed sars-cov-2 infection. 4. informed consent obtained . 5. hypoxia (spo2\<95%). 6. documented lung opacities/infiltrates. 7. confirmed hyperinflammation.

inclusion criteria: men or women with age ≥18 and ≤85 years. in case of women of childbearing potential (wocbp), they should confirm menstrual period and a negative highly sensitive urine or serum pregnancy test to be included. laboratory-confirmed sars-cov-2 infection. informed consent obtained . hypoxia (spo2<95%). documented lung opacities/infiltrates. confirmed hyperinflammation.

inclusion criteria: men or women with age ≥18 and ≤85 years. in case of women of childbearing potential (wocbp), they should confirm menstrual period and a negative highly sensitive urine or serum pregnancy test to be included. laboratory-confirmed sars-cov-2 infection. informed consent obtained . hypoxia (spo2<95%). documented lung opacities/infiltrates. confirmed hyperinflammation.