* patients on mechanical ventilation * patients who are pregnant or breastfeeding * patients with multi-organ failure * patients with advanced malignancy receiving cytotoxic chemotherapy * patients with prior history of solid organ (kidney, liver, heart, lung, pancreas) or bone marrow transplant * patients on any other immunomodulatory therapy * patients receiving plaquenil * patients who have participated in an investigational drug or device trial in previous 30 days * patients with a history of allergy or intolerance to ta1 * any other medical or psychiatric condition that, in the opinion of the investigator, would compromise patient safety or interfere with the objectives of the protocol or completion of the protocol treatment

* patients on mechanical ventilation * patients who are pregnant or breastfeeding * patients with multi-organ failure * patients with advanced malignancy receiving cytotoxic chemotherapy * patients with prior history of solid organ (kidney, liver, heart, lung, pancreas) or bone marrow transplant * patients on any other immunomodulatory therapy * patients receiving plaquenil * patients who have participated in an investigational drug or device trial in previous 30 days * patients with a history of allergy or intolerance to ta1 * any other medical or psychiatric condition that, in the opinion of the investigator, would compromise patient safety or interfere with the objectives of the protocol or completion of the protocol treatment

- patients on mechanical ventilation - patients who are pregnant or breastfeeding - patients with multi-organ failure - patients with advanced malignancy receiving cytotoxic chemotherapy - patients with prior history of solid organ (kidney, liver, heart, lung, pancreas) or bone marrow transplant - patients on any other immunomodulatory therapy - patients receiving plaquenil - patients who have participated in an investigational drug or device trial in previous 30 days - patients with a history of allergy or intolerance to ta1 - any other medical or psychiatric condition that, in the opinion of the investigator, would compromise patient safety or interfere with the objectives of the protocol or completion of the protocol treatment

- patients on mechanical ventilation - patients who are pregnant or breastfeeding - patients with multi-organ failure - patients with advanced malignancy receiving cytotoxic chemotherapy - patients with prior history of solid organ (kidney, liver, heart, lung, pancreas) or bone marrow transplant - patients on any other immunomodulatory therapy - patients receiving plaquenil - patients who have participated in an investigational drug or device trial in previous 30 days - patients with a history of allergy or intolerance to ta1 - any other medical or psychiatric condition that, in the opinion of the investigator, would compromise patient safety or interfere with the objectives of the protocol or completion of the protocol treatment