* pregnancy, lactation; * known hypersensitivity to colchicine * known hepatic failure * egfr\<20 ml/min * clinical estimation that the patient will require mechanical respiratory support in less than 24 hours * any clinical estimation of the attending physician under which the patient shall be excluded * qtc \> 450 msec (colchicine is not known to significantly prolong qtc, but may interact with other medications which prolong qtc). * participation in another clinical trial * under colchicine treatment for other indications * patient who is not likely to comply to study procedures

* pregnancy, lactation; * known hypersensitivity to colchicine * known hepatic failure * egfr\<20 ml/min * clinical estimation that the patient will require mechanical respiratory support in less than 24 hours * any clinical estimation of the attending physician under which the patient shall be excluded * qtc \> 450 msec (colchicine is not known to significantly prolong qtc, but may interact with other medications which prolong qtc). * participation in another clinical trial * under colchicine treatment for other indications * patient who is not likely to comply to study procedures

- pregnancy, lactation; - known hypersensitivity to colchicine - known hepatic failure - egfr<20 ml/min - clinical estimation that the patient will require mechanical respiratory support in less than 24 hours - any clinical estimation of the attending physician under which the patient shall be excluded - qtc > 450 msec (colchicine is not known to significantly prolong qtc, but may interact with other medications which prolong qtc). - participation in another clinical trial - under colchicine treatment for other indications - patient who is not likely to comply to study procedures

- pregnancy, lactation; - known hypersensitivity to colchicine - known hepatic failure - egfr<20 ml/min - clinical estimation that the patient will require mechanical respiratory support in less than 24 hours - any clinical estimation of the attending physician under which the patient shall be excluded - qtc > 450 msec (colchicine is not known to significantly prolong qtc, but may interact with other medications which prolong qtc). - participation in another clinical trial - under colchicine treatment for other indications - patient who is not likely to comply to study procedures