inclusion criteria: a.core platform (all participants must meet the following): 1. adult (as defined by local jurisdiction) patient admitted to hospital with acute illness and suspected or proven sars-cov-2 infection. b. antiviral ii domain (all participants in the antiviral ii domain must meet the following): 1. sars-cov-2 infection has been confirmed by positive rapid antigen test or polymerase chain reaction test within the last 7 days

inclusion criteria: a.core platform (all participants must meet the following): 1. adult (as defined by local jurisdiction) patient admitted to hospital with acute illness and suspected or proven sars-cov-2 infection. b. antiviral ii domain (all participants in the antiviral ii domain must meet the following): 1. sars-cov-2 infection has been confirmed by positive rapid antigen test or polymerase chain reaction test within the last 7 days

platform inclusion criteria: age ≥ 18 years admitted to an acute-care hospital confirmed sars-cov-2 by nucleic acid testing or rapid antigen testing in the 14 days prior to randomisation able to be randomised within 14 days of symptom onset at least one symptom or sign attributable to sars-cov-2 infection

platform inclusion criteria: age ≥ 18 years admitted to an acute-care hospital confirmed sars-cov-2 by nucleic acid testing or rapid antigen testing in the 14 days prior to randomisation able to be randomised within 14 days of symptom onset at least one symptom or sign attributable to sars-cov-2 infection

platform inclusion criteria: age ≥ 18 years admitted to an acute-care hospital confirmed sars-cov-2 by nucleic acid testing in the past 14 days able to be randomised within 14 days of symptom onset at least one symptom or sign attributable to sars-cov-2 infection

platform inclusion criteria: age ≥ 18 years admitted to an acute-care hospital confirmed sars-cov-2 by nucleic acid testing in the past 14 days able to be randomised within 14 days of symptom onset at least one symptom or sign attributable to sars-cov-2 infection

platform inclusion criteria: 1. age ≥ 18 years 2. admitted to an acute-care hospital 3. confirmed sars-cov-2 by nucleic acid testing in the past 14 days 4. able to be randomised within 14 days of symptom onset 5. at least one symptom or sign attributable to sars-cov-2 infection

platform inclusion criteria: 1. age ≥ 18 years 2. admitted to an acute-care hospital 3. confirmed sars-cov-2 by nucleic acid testing in the past 14 days 4. able to be randomised within 14 days of symptom onset 5. at least one symptom or sign attributable to sars-cov-2 infection

inclusion criteria: 1. age ≥ 18 years 2. confirmed sars-cov-2 by nucleic acid testing in the past 12 days 3. able to be randomised within 12 days of symptom onset 4. expected to be remain an inpatient for at least 48 hours from the time of randomisation

inclusion criteria: 1. age ≥ 18 years 2. confirmed sars-cov-2 by nucleic acid testing in the past 12 days 3. able to be randomised within 12 days of symptom onset 4. expected to be remain an inpatient for at least 48 hours from the time of randomisation