inclusion criteria: 1. male or female participants ≥ 18 years of age. 2. participants with sars-cov-2 infection, as defined by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent test. 3. must have pulmonary infiltrate on radiologic examination. 4. participant must have a clinical diagnosis of high-risk ards (as defined by a pao2-to-fio2 ratio of \< 150 mm hg) requiring intensive respiratory support, including non-invasive methods such as high-flow nasal cannula or mechanical ventilation. 5. ast and alt ≤ 3 x upper limit of normal (uln). 6. consent must be given before performance of any study related procedure not part of standard medical care, with the understanding that consent may be withdrawn at any time without prejudice to future medical care. informed consent can be obtained from healthcare proxy if the participant is unable to provide consent due to medical status.

inclusion criteria: 1. male or female participants ≥ 18 years of age. 2. participants with sars-cov-2 infection, as defined by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent test. 3. must have pulmonary infiltrate on radiologic examination. 4. participant must have a clinical diagnosis of high-risk ards (as defined by a pao2-to-fio2 ratio of \< 150 mm hg) requiring intensive respiratory support, including non-invasive methods such as high-flow nasal cannula or mechanical ventilation. 5. ast and alt ≤ 3 x upper limit of normal (uln). 6. consent must be given before performance of any study related procedure not part of standard medical care, with the understanding that consent may be withdrawn at any time without prejudice to future medical care. informed consent can be obtained from healthcare proxy if the participant is unable to provide consent due to medical status.

inclusion criteria: male or female participants ≥ 18 years of age. participants with sars-cov-2 infection, as defined by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent test. must have pulmonary infiltrate on radiologic examination. participant must have a clinical diagnosis of high-risk ards (as defined by a pao2-to-fio2 ratio of < 150 mm hg) requiring intensive respiratory support, including non-invasive methods such as high-flow nasal cannula or mechanical ventilation. ast and alt ≤ 3 x upper limit of normal (uln). consent must be given before performance of any study related procedure not part of standard medical care, with the understanding that consent may be withdrawn at any time without prejudice to future medical care. informed consent can be obtained from healthcare proxy if the participant is unable to provide consent due to medical status.

inclusion criteria: male or female participants ≥ 18 years of age. participants with sars-cov-2 infection, as defined by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent test. must have pulmonary infiltrate on radiologic examination. participant must have a clinical diagnosis of high-risk ards (as defined by a pao2-to-fio2 ratio of < 150 mm hg) requiring intensive respiratory support, including non-invasive methods such as high-flow nasal cannula or mechanical ventilation. ast and alt ≤ 3 x upper limit of normal (uln). consent must be given before performance of any study related procedure not part of standard medical care, with the understanding that consent may be withdrawn at any time without prejudice to future medical care. informed consent can be obtained from healthcare proxy if the participant is unable to provide consent due to medical status.

inclusion criteria: 1. male or female participants ≥ 18 years of age. 2. participants with sars-cov-2 infection, as defined by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent test. 3. must have pulmonary infiltrate on radiologic examination. 4. participant must have a clinical diagnosis of high-risk ards (as defined by a pao2-to-fio2 ratio of < 150 mm hg) requiring intensive respiratory support, including non-invasive methods such as high-flow nasal cannula or mechanical ventilation. 5. ast and alt ≤ 3 x upper limit of normal (uln). 6. consent must be given before performance of any study related procedure not part of standard medical care, with the understanding that consent may be withdrawn at any time without prejudice to future medical care. informed consent can be obtained from healthcare proxy if the participant is unable to provide consent due to medical status.

inclusion criteria: 1. male or female participants ≥ 18 years of age. 2. participants with sars-cov-2 infection, as defined by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent test. 3. must have pulmonary infiltrate on radiologic examination. 4. participant must have a clinical diagnosis of high-risk ards (as defined by a pao2-to-fio2 ratio of < 150 mm hg) requiring intensive respiratory support, including non-invasive methods such as high-flow nasal cannula or mechanical ventilation. 5. ast and alt ≤ 3 x upper limit of normal (uln). 6. consent must be given before performance of any study related procedure not part of standard medical care, with the understanding that consent may be withdrawn at any time without prejudice to future medical care. informed consent can be obtained from healthcare proxy if the participant is unable to provide consent due to medical status.

inclusion criteria: 1. male or female participants ≥ 18 years of age. 2. participants with sars-cov-2 infection, as defined by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent test. 3. must have pulmonary infiltrate on radiologic examination. 4. participant must be status-post intubation and mechanical ventilation (or, extracorporeal membrane oxygenation, ecmo) no more than 4 days from rapa-501 infusion (surrogate for participant provides informed consent). 5. ast and alt ≤ 3 x upper limit of normal (uln). 6. consent must be given before performance of any study related procedure not part of standard medical care, with the understanding that consent may be withdrawn at any time without prejudice to future medical care. informed consent can be obtained from healthcare proxy if the participant is unable to provide consent due to medical status.

inclusion criteria: 1. male or female participants ≥ 18 years of age. 2. participants with sars-cov-2 infection, as defined by standard reverse transcriptase polymerase chain reaction (rt-pcr) assay or equivalent test. 3. must have pulmonary infiltrate on radiologic examination. 4. participant must be status-post intubation and mechanical ventilation (or, extracorporeal membrane oxygenation, ecmo) no more than 4 days from rapa-501 infusion (surrogate for participant provides informed consent). 5. ast and alt ≤ 3 x upper limit of normal (uln). 6. consent must be given before performance of any study related procedure not part of standard medical care, with the understanding that consent may be withdrawn at any time without prejudice to future medical care. informed consent can be obtained from healthcare proxy if the participant is unable to provide consent due to medical status.