inclusion criteria: 1. healthy males or females aged 21 to 80 at the time of informed consent. 2. body mass index 18-35 kg/m2, inclusive, at screening 3. willing to refrain from strenuous exercise/activity (for example heavy lifting, weight training, intense aerobics classes etc.) and alcohol for at least 72 hours prior to study visits 4. temperature is less than 99.3 degrees fahrenheit (37.4 degrees celsius) at screening and at the pre-dose evaluation on day 1 5. willing and able to comply with protocol-defined procedures and complete all study visits 6. males must be surgically sterile or willing to use adequate contraception; females must be post-menopausal, surgically sterile or willing to use adequate contraception

inclusion criteria: 1. healthy males or females aged 21 to 80 at the time of informed consent. 2. body mass index 18-35 kg/m2, inclusive, at screening 3. willing to refrain from strenuous exercise/activity (for example heavy lifting, weight training, intense aerobics classes etc.) and alcohol for at least 72 hours prior to study visits 4. temperature is less than 99.3 degrees fahrenheit (37.4 degrees celsius) at screening and at the pre-dose evaluation on day 1 5. willing and able to comply with protocol-defined procedures and complete all study visits 6. males must be surgically sterile or willing to use adequate contraception; females must be post-menopausal, surgically sterile or willing to use adequate contraception

inclusion criteria: healthy males or females aged 21 to 80 at the time of informed consent. body mass index 18-35 kg/m2, inclusive, at screening willing to refrain from strenuous exercise/activity (for example heavy lifting, weight training, intense aerobics classes etc.) and alcohol for at least 72 hours prior to study visits temperature is less than 99.3 degrees fahrenheit (37.4 degrees celsius) at screening and at the pre-dose evaluation on day 1 willing and able to comply with protocol-defined procedures and complete all study visits males must be surgically sterile or willing to use adequate contraception; females must be post-menopausal, surgically sterile or willing to use adequate contraception

inclusion criteria: healthy males or females aged 21 to 80 at the time of informed consent. body mass index 18-35 kg/m2, inclusive, at screening willing to refrain from strenuous exercise/activity (for example heavy lifting, weight training, intense aerobics classes etc.) and alcohol for at least 72 hours prior to study visits temperature is less than 99.3 degrees fahrenheit (37.4 degrees celsius) at screening and at the pre-dose evaluation on day 1 willing and able to comply with protocol-defined procedures and complete all study visits males must be surgically sterile or willing to use adequate contraception; females must be post-menopausal, surgically sterile or willing to use adequate contraception

inclusion criteria: 1. healthy males or females aged 21 to 80 at the time of informed consent. 2. body mass index 18-35 kg/m2, inclusive, at screening 3. willing to refrain from strenuous exercise/activity (for example heavy lifting, weight training, intense aerobics classes etc.) and alcohol for at least 72 hours prior to study visits 4. temperature is less than 99.3 degrees fahrenheit (37.4 degrees celsius) at screening and at the pre-dose evaluation on day 1 5. willing and able to comply with protocol-defined procedures and complete all study visits 6. males must be surgically sterile or willing to use adequate contraception; females must be post-menopausal, surgically sterile or willing to use adequate contraception

inclusion criteria: 1. healthy males or females aged 21 to 80 at the time of informed consent. 2. body mass index 18-35 kg/m2, inclusive, at screening 3. willing to refrain from strenuous exercise/activity (for example heavy lifting, weight training, intense aerobics classes etc.) and alcohol for at least 72 hours prior to study visits 4. temperature is less than 99.3 degrees fahrenheit (37.4 degrees celsius) at screening and at the pre-dose evaluation on day 1 5. willing and able to comply with protocol-defined procedures and complete all study visits 6. males must be surgically sterile or willing to use adequate contraception; females must be post-menopausal, surgically sterile or willing to use adequate contraception