* any clinically significant chronic or acute medical condition that makes the volunteer unsuitable for participation; * a history of significant hypersensitivity, intolerance, or allergy to any drug compound; * history of alcohol or other substance abuse;

* any clinically significant chronic or acute medical condition that makes the volunteer unsuitable for participation; * a history of significant hypersensitivity, intolerance, or allergy to any drug compound; * history of alcohol or other substance abuse;

- any clinically significant chronic or acute medical condition that makes the volunteer unsuitable for participation; - a history of significant hypersensitivity, intolerance, or allergy to any drug compound; - history of alcohol or other substance abuse;

- any clinically significant chronic or acute medical condition that makes the volunteer unsuitable for participation; - a history of significant hypersensitivity, intolerance, or allergy to any drug compound; - history of alcohol or other substance abuse;