inclusion criteria: * with severe non-critical stage of covid at the time of admission. * patients tested positive for sars-cov-2 confirmed by pcr (polymerase chain reaction) or quick antigen test * within the first 12 days post appearance of symptoms * with at least one of the following risk factors: diabetes mellitus (dm), obesity (bmi\>30, hypertension, age \> 65 years. * respiratory rate 25-34/min and no signs of respiratory distress. * with at least two of the following indicators of severity: spo2 81-90%, pafi 150-300 mmhg, fio2\>60% , lung damage in thorax radiographic image =\> 25% as determined by rale score (an equivalent to 2-4). * normal liver function (considered up to a fivefold increase above the normal limits of hepatic transaminases) * signed informed consent

inclusion criteria: * with severe non-critical stage of covid at the time of admission. * patients tested positive for sars-cov-2 confirmed by pcr (polymerase chain reaction) or quick antigen test * within the first 12 days post appearance of symptoms * with at least one of the following risk factors: diabetes mellitus (dm), obesity (bmi\>30, hypertension, age \> 65 years. * respiratory rate 25-34/min and no signs of respiratory distress. * with at least two of the following indicators of severity: spo2 81-90%, pafi 150-300 mmhg, fio2\>60% , lung damage in thorax radiographic image =\> 25% as determined by rale score (an equivalent to 2-4). * normal liver function (considered up to a fivefold increase above the normal limits of hepatic transaminases) * signed informed consent

inclusion criteria: with severe non-critical stage of covid at the time of admission. patients tested positive for sars-cov-2 confirmed by pcr (polymerase chain reaction) or quick antigen test within the first 12 days post appearance of symptoms with at least one of the following risk factors: diabetes mellitus (dm), obesity (bmi>30, hypertension, age > 65 years. respiratory rate 25-34/min and no signs of respiratory distress. with at least two of the following indicators of severity: spo2 81-90%, pafi 150-300 mmhg, fio2>60% , lung damage in thorax radiographic image => 25% as determined by rale score (an equivalent to 2-4). normal liver function (considered up to a fivefold increase above the normal limits of hepatic transaminases) signed informed consent

inclusion criteria: with severe non-critical stage of covid at the time of admission. patients tested positive for sars-cov-2 confirmed by pcr (polymerase chain reaction) or quick antigen test within the first 12 days post appearance of symptoms with at least one of the following risk factors: diabetes mellitus (dm), obesity (bmi>30, hypertension, age > 65 years. respiratory rate 25-34/min and no signs of respiratory distress. with at least two of the following indicators of severity: spo2 81-90%, pafi 150-300 mmhg, fio2>60% , lung damage in thorax radiographic image => 25% as determined by rale score (an equivalent to 2-4). normal liver function (considered up to a fivefold increase above the normal limits of hepatic transaminases) signed informed consent

inclusion criteria: - with severe non-critical stage of covid at the time of admission. - patients tested positive for sars-cov-2 confirmed by pcr (polymerase chain reaction) - within the first 12 days post appearance of symptoms - with at least one of the following risk factors: diabetes mellitus (dm), obesity (bmi>30, hypertension, age > 65 years. - respiratory rate 25-34/min and no signs of respiratory distress. - thorax usg with lus (lung ultrasonographic score)>23 - with at least two of the following indicators of severity: spo2 81-90%, pafi 250-100 mmhg, fio2>60% , lhd (lactic acid dehydrogenase) >350 u/l, lung infiltration >50% determined by thorax radiography. - normal liver function (considered up to a fivefold increase above the normal limits of hepatic transaminases) - signed informed consent

inclusion criteria: - with severe non-critical stage of covid at the time of admission. - patients tested positive for sars-cov-2 confirmed by pcr (polymerase chain reaction) - within the first 12 days post appearance of symptoms - with at least one of the following risk factors: diabetes mellitus (dm), obesity (bmi>30, hypertension, age > 65 years. - respiratory rate 25-34/min and no signs of respiratory distress. - thorax usg with lus (lung ultrasonographic score)>23 - with at least two of the following indicators of severity: spo2 81-90%, pafi 250-100 mmhg, fio2>60% , lhd (lactic acid dehydrogenase) >350 u/l, lung infiltration >50% determined by thorax radiography. - normal liver function (considered up to a fivefold increase above the normal limits of hepatic transaminases) - signed informed consent