1. diagnosed with severe pneumonia 2. patients with clinically significant cardiovascular disease (including arrhythmia, qtc interval prolongation) 3. patients with clinically significant anemia (hemoglobin \<8.0 g/dl) 4. patient with known allergic reaction or contraindication to any of the investigational medicinal product (pyronaridine tetraphosphate, artesunate) 5. patients with known history of galactose intolerance, lapp lactase deficiency or glucose-galactose malabsorption, etc. 6. patients with the gastrointestinal disease and surgery to affect the absorption, distribution, metabolism and excretion of the drug, active gastritis, gastrointestinal tract / rectal bleeding, gastric ulcer, pancreatitis abnormalities (except simple appendectomy or hernia surgery) 7. patients who received antiviral drugs that is intended to treat covid-19, within 28 days prior to screening evaluation (can be enrolled into the study, if the patient has gone through a sufficient wash-out period) 8. patients with known severe renal impairment (estimated glomerular filtration rate ≤30 ml/min/1.73 m2) 9. patients with known severe liver disease (i.e. alt or ast\>5 times upper limit, nausea, abdominal pain associated with jaundice or child-pugh stage b or c) 10. viral disease (hiv, hbv, hcv, etc.) other than covid-19 that require administration of other antiviral agents 11. patients that require ventilation therapy (e.g. non-invasive ventilation, invasive mechanical ventilation, extracorporeal membrane oxygenation, etc.) 12. patients with chronic underlying disease (e.g. uncontrolled diabetes mellitus, chronic kidney disease, chronic liver disease, chronic pulmonary disease, chronic cardiovascular disease, blood cancer, cancer patients with cancer treatment, patients taking immunosuppressants), highly obese patients, dialysis patients, and transplant patients that are determined by the physician, to be not suitable for trial involvement. 13. pregnant or lactating women 14. male or female of childbearing potential who has plans to become pregnant during the study period and for three months after the clinical study or who is not willing to take appropriate contraceptive measures \*hormonal contraception (contraceptive implant, injections, pills, etc.), iuds, condoms (male) and contraceptive diaphragm or cap (female), sterilization (vasectomy, tubal ligation, etc.) 15. participating in another clinical trial currently or within 28 days from signing the informed consent 16. patients that are deemed ineligible to participate in the clinical trial by the investigator

1. diagnosed with severe pneumonia 2. patients with clinically significant cardiovascular disease (including arrhythmia, qtc interval prolongation) 3. patients with clinically significant anemia (hemoglobin \<8.0 g/dl) 4. patient with known allergic reaction or contraindication to any of the investigational medicinal product (pyronaridine tetraphosphate, artesunate) 5. patients with known history of galactose intolerance, lapp lactase deficiency or glucose-galactose malabsorption, etc. 6. patients with the gastrointestinal disease and surgery to affect the absorption, distribution, metabolism and excretion of the drug, active gastritis, gastrointestinal tract / rectal bleeding, gastric ulcer, pancreatitis abnormalities (except simple appendectomy or hernia surgery) 7. patients who received antiviral drugs that is intended to treat covid-19, within 28 days prior to screening evaluation (can be enrolled into the study, if the patient has gone through a sufficient wash-out period) 8. patients with known severe renal impairment (estimated glomerular filtration rate ≤30 ml/min/1.73 m2) 9. patients with known severe liver disease (i.e. alt or ast\>5 times upper limit, nausea, abdominal pain associated with jaundice or child-pugh stage b or c) 10. viral disease (hiv, hbv, hcv, etc.) other than covid-19 that require administration of other antiviral agents 11. patients that require ventilation therapy (e.g. non-invasive ventilation, invasive mechanical ventilation, extracorporeal membrane oxygenation, etc.) 12. patients with chronic underlying disease (e.g. uncontrolled diabetes mellitus, chronic kidney disease, chronic liver disease, chronic pulmonary disease, chronic cardiovascular disease, blood cancer, cancer patients with cancer treatment, patients taking immunosuppressants), highly obese patients, dialysis patients, and transplant patients that are determined by the physician, to be not suitable for trial involvement. 13. pregnant or lactating women 14. male or female of childbearing potential who has plans to become pregnant during the study period and for three months after the clinical study or who is not willing to take appropriate contraceptive measures \*hormonal contraception (contraceptive implant, injections, pills, etc.), iuds, condoms (male) and contraceptive diaphragm or cap (female), sterilization (vasectomy, tubal ligation, etc.) 15. participating in another clinical trial currently or within 28 days from signing the informed consent 16. patients that are deemed ineligible to participate in the clinical trial by the investigator

diagnosed with severe pneumonia patients with clinically significant cardiovascular disease (including arrhythmia, qtc interval prolongation) patients with clinically significant anemia (hemoglobin <8.0 g/dl) patient with known allergic reaction or contraindication to any of the investigational medicinal product (pyronaridine tetraphosphate, artesunate) patients with known history of galactose intolerance, lapp lactase deficiency or glucose-galactose malabsorption, etc. patients with the gastrointestinal disease and surgery to affect the absorption, distribution, metabolism and excretion of the drug, active gastritis, gastrointestinal tract / rectal bleeding, gastric ulcer, pancreatitis abnormalities (except simple appendectomy or hernia surgery) patients who received antiviral drugs that is intended to treat covid-19, within 28 days prior to screening evaluation (can be enrolled into the study, if the patient has gone through a sufficient wash-out period) patients with known severe renal impairment (estimated glomerular filtration rate ≤30 ml/min/1.73 m2) patients with known severe liver disease (i.e. alt or ast>5 times upper limit, nausea, abdominal pain associated with jaundice or child-pugh stage b or c) viral disease (hiv, hbv, hcv, etc.) other than covid-19 that require administration of other antiviral agents patients that require ventilation therapy (e.g. non-invasive ventilation, invasive mechanical ventilation, extracorporeal membrane oxygenation, etc.) patients with chronic underlying disease (e.g. uncontrolled diabetes mellitus, chronic kidney disease, chronic liver disease, chronic pulmonary disease, chronic cardiovascular disease, blood cancer, cancer patients with cancer treatment, patients taking immunosuppressants), highly obese patients, dialysis patients, and transplant patients that are determined by the physician, to be not suitable for trial involvement. pregnant or lactating women male or female of childbearing potential who has plans to become pregnant during the study period and for three months after the clinical study or who is not willing to take appropriate contraceptive measures *hormonal contraception (contraceptive implant, injections, pills, etc.), iuds, condoms (male) and contraceptive diaphragm or cap (female), sterilization (vasectomy, tubal ligation, etc.) participating in another clinical trial currently or within 28 days from signing the informed consent patients that are deemed ineligible to participate in the clinical trial by the investigator

diagnosed with severe pneumonia patients with clinically significant cardiovascular disease (including arrhythmia, qtc interval prolongation) patients with clinically significant anemia (hemoglobin <8.0 g/dl) patient with known allergic reaction or contraindication to any of the investigational medicinal product (pyronaridine tetraphosphate, artesunate) patients with known history of galactose intolerance, lapp lactase deficiency or glucose-galactose malabsorption, etc. patients with the gastrointestinal disease and surgery to affect the absorption, distribution, metabolism and excretion of the drug, active gastritis, gastrointestinal tract / rectal bleeding, gastric ulcer, pancreatitis abnormalities (except simple appendectomy or hernia surgery) patients who received antiviral drugs that is intended to treat covid-19, within 28 days prior to screening evaluation (can be enrolled into the study, if the patient has gone through a sufficient wash-out period) patients with known severe renal impairment (estimated glomerular filtration rate ≤30 ml/min/1.73 m2) patients with known severe liver disease (i.e. alt or ast>5 times upper limit, nausea, abdominal pain associated with jaundice or child-pugh stage b or c) viral disease (hiv, hbv, hcv, etc.) other than covid-19 that require administration of other antiviral agents patients that require ventilation therapy (e.g. non-invasive ventilation, invasive mechanical ventilation, extracorporeal membrane oxygenation, etc.) patients with chronic underlying disease (e.g. uncontrolled diabetes mellitus, chronic kidney disease, chronic liver disease, chronic pulmonary disease, chronic cardiovascular disease, blood cancer, cancer patients with cancer treatment, patients taking immunosuppressants), highly obese patients, dialysis patients, and transplant patients that are determined by the physician, to be not suitable for trial involvement. pregnant or lactating women male or female of childbearing potential who has plans to become pregnant during the study period and for three months after the clinical study or who is not willing to take appropriate contraceptive measures *hormonal contraception (contraceptive implant, injections, pills, etc.), iuds, condoms (male) and contraceptive diaphragm or cap (female), sterilization (vasectomy, tubal ligation, etc.) participating in another clinical trial currently or within 28 days from signing the informed consent patients that are deemed ineligible to participate in the clinical trial by the investigator

1. diagnosed with severe pneumonia 2. patients with clinically significant cardiovascular disease (including arrhythmia, qtc interval prolongation) 3. patients with clinically significant anemia (hemoglobin <8.0 g/dl) 4. patient with known allergic reaction or contraindication to any of the investigational medicinal product (pyronaridine tetraphosphate, artesunate) 5. patients with known history of galactose intolerance, lapp lactase deficiency or glucose-galactose malabsorption, etc. 6. patients with the gastrointestinal disease and surgery to affect the absorption, distribution, metabolism and excretion of the drug, active gastritis, gastrointestinal tract / rectal bleeding, gastric ulcer, pancreatitis abnormalities (except simple appendectomy or hernia surgery) 7. patients who received antiviral drugs that is intended to treat covid-19, within 28 days prior to screening evaluation (can be enrolled into the study, if the patient has gone through a sufficient wash-out period) 8. patients with known severe renal impairment (estimated glomerular filtration rate ≤30 ml/min/1.73 m2) 9. patients with known severe liver disease (i.e. alt or ast>5 times upper limit, nausea, abdominal pain associated with jaundice or child-pugh stage b or c) 10. viral disease (hiv, hbv, hcv, etc.) other than covid-19 that require administration of other antiviral agents 11. patients that require ventilation therapy (e.g. non-invasive ventilation, invasive mechanical ventilation, extracorporeal membrane oxygenation, etc.) 12. patients with chronic underlying disease (e.g. uncontrolled diabetes mellitus, chronic kidney disease, chronic liver disease, chronic pulmonary disease, chronic cardiovascular disease, blood cancer, cancer patients with cancer treatment, patients taking immunosuppressants), highly obese patients, dialysis patients, and transplant patients that are determined by the physician, to be not suitable for trial involvement. 13. pregnant or lactating women 14. male or female of childbearing potential who has plans to become pregnant during the study period and for three months after the clinical study or who is not willing to take appropriate contraceptive measures *hormonal contraception (contraceptive implant, injections, pills, etc.), iuds, condoms (male) and contraceptive diaphragm or cap (female), sterilization (vasectomy, tubal ligation, etc.) 15. participating in another clinical trial currently or within 28 days from signing the informed consent 16. patients that are deemed ineligible to participate in the clinical trial by the investigator

1. diagnosed with severe pneumonia 2. patients with clinically significant cardiovascular disease (including arrhythmia, qtc interval prolongation) 3. patients with clinically significant anemia (hemoglobin <8.0 g/dl) 4. patient with known allergic reaction or contraindication to any of the investigational medicinal product (pyronaridine tetraphosphate, artesunate) 5. patients with known history of galactose intolerance, lapp lactase deficiency or glucose-galactose malabsorption, etc. 6. patients with the gastrointestinal disease and surgery to affect the absorption, distribution, metabolism and excretion of the drug, active gastritis, gastrointestinal tract / rectal bleeding, gastric ulcer, pancreatitis abnormalities (except simple appendectomy or hernia surgery) 7. patients who received antiviral drugs that is intended to treat covid-19, within 28 days prior to screening evaluation (can be enrolled into the study, if the patient has gone through a sufficient wash-out period) 8. patients with known severe renal impairment (estimated glomerular filtration rate ≤30 ml/min/1.73 m2) 9. patients with known severe liver disease (i.e. alt or ast>5 times upper limit, nausea, abdominal pain associated with jaundice or child-pugh stage b or c) 10. viral disease (hiv, hbv, hcv, etc.) other than covid-19 that require administration of other antiviral agents 11. patients that require ventilation therapy (e.g. non-invasive ventilation, invasive mechanical ventilation, extracorporeal membrane oxygenation, etc.) 12. patients with chronic underlying disease (e.g. uncontrolled diabetes mellitus, chronic kidney disease, chronic liver disease, chronic pulmonary disease, chronic cardiovascular disease, blood cancer, cancer patients with cancer treatment, patients taking immunosuppressants), highly obese patients, dialysis patients, and transplant patients that are determined by the physician, to be not suitable for trial involvement. 13. pregnant or lactating women 14. male or female of childbearing potential who has plans to become pregnant during the study period and for three months after the clinical study or who is not willing to take appropriate contraceptive measures *hormonal contraception (contraceptive implant, injections, pills, etc.), iuds, condoms (male) and contraceptive diaphragm or cap (female), sterilization (vasectomy, tubal ligation, etc.) 15. participating in another clinical trial currently or within 28 days from signing the informed consent 16. patients that are deemed ineligible to participate in the clinical trial by the investigator