inclusion criteria: * participant must be ≥18 years and ≤80 years of age inclusive, at the time of signing the informed consent. * hospitalized (or documentation of a plan to admit to the hospital if the participant is in an emergency department) with evidence of covid-19 lung disease diagnosed by chest radiograph, chest computed tomography or chest auscultation (rales, crackles) and with severe disease defined as follows: the participant requires supplemental oxygen administered by nasal cannula, simple face mask, or other similar oxygen delivery device (ie, increase in oxygen requirement following sars-cov-2 infection). * sars-cov-2 infection confirmed by rt-pcr, or other commercial or public health assay in any specimen, within 3 weeks prior to randomization, and no alternative explanation for current clinical condition. * at time of randomization, have demonstrated laboratory signs consistent with systemic inflammation. * male and/or female participants, including women of childbearing potential (wocbp). * capable of giving signed informed consent.

inclusion criteria: * participant must be ≥18 years and ≤80 years of age inclusive, at the time of signing the informed consent. * hospitalized (or documentation of a plan to admit to the hospital if the participant is in an emergency department) with evidence of covid-19 lung disease diagnosed by chest radiograph, chest computed tomography or chest auscultation (rales, crackles) and with severe disease defined as follows: the participant requires supplemental oxygen administered by nasal cannula, simple face mask, or other similar oxygen delivery device (ie, increase in oxygen requirement following sars-cov-2 infection). * sars-cov-2 infection confirmed by rt-pcr, or other commercial or public health assay in any specimen, within 3 weeks prior to randomization, and no alternative explanation for current clinical condition. * at time of randomization, have demonstrated laboratory signs consistent with systemic inflammation. * male and/or female participants, including women of childbearing potential (wocbp). * capable of giving signed informed consent.

inclusion criteria: - participant must be ≥18 years and ≤80 years of age inclusive, at the time of signing the informed consent. - hospitalized (or documentation of a plan to admit to the hospital if the participant is in an emergency department) with evidence of covid-19 lung disease diagnosed by chest radiograph, chest computed tomography or chest auscultation (rales, crackles) and with severe disease defined as follows: the participant requires supplemental oxygen administered by nasal cannula, simple face mask, or other similar oxygen delivery device (ie, increase in oxygen requirement following sars-cov-2 infection). - sars-cov-2 infection confirmed by rt-pcr, or other commercial or public health assay in any specimen, within 3 weeks prior to randomization, and no alternative explanation for current clinical condition. - at time of randomization, have demonstrated laboratory signs consistent with systemic inflammation. - male and/or female participants, including women of childbearing potential (wocbp). - capable of giving signed informed consent.

inclusion criteria: - participant must be ≥18 years and ≤80 years of age inclusive, at the time of signing the informed consent. - hospitalized (or documentation of a plan to admit to the hospital if the participant is in an emergency department) with evidence of covid-19 lung disease diagnosed by chest radiograph, chest computed tomography or chest auscultation (rales, crackles) and with severe disease defined as follows: the participant requires supplemental oxygen administered by nasal cannula, simple face mask, or other similar oxygen delivery device (ie, increase in oxygen requirement following sars-cov-2 infection). - sars-cov-2 infection confirmed by rt-pcr, or other commercial or public health assay in any specimen, within 3 weeks prior to randomization, and no alternative explanation for current clinical condition. - at time of randomization, have demonstrated laboratory signs consistent with systemic inflammation. - male and/or female participants, including women of childbearing potential (wocbp). - capable of giving signed informed consent.