* hypersensitivity to natural or recombinant interferon-ß * hypersensitivity to human albumin or mannitol * recent suicide attempt * decompensation of liver failure * age \< 18 years * pregnant or nursing. * patients managed on an outpatient basis (i.e. not initially hospitalized). * parenteral ifn treatment. in periode b, addition of new exclusion criteria * patients with kidney transplant * immunocompromised patients * patients with severe systemic disease constantly threatening their vital prognosis (asa ≥ iv: e.g. severe arf, advanced cancer pathology, recent myocardial idm, severe valvular dysfunction, dependence on parenteral nutrition on central line, shock, sepsis, trauma, ...). * patients in septic shock. * patients with documented fungal infection. * patients on mechanical ventilation. * patients hospitalized for covid-19 for more than 7 days.

* hypersensitivity to natural or recombinant interferon-ß * hypersensitivity to human albumin or mannitol * recent suicide attempt * decompensation of liver failure * age \< 18 years * pregnant or nursing. * patients managed on an outpatient basis (i.e. not initially hospitalized). * parenteral ifn treatment. in periode b, addition of new exclusion criteria * patients with kidney transplant * immunocompromised patients * patients with severe systemic disease constantly threatening their vital prognosis (asa ≥ iv: e.g. severe arf, advanced cancer pathology, recent myocardial idm, severe valvular dysfunction, dependence on parenteral nutrition on central line, shock, sepsis, trauma, ...). * patients in septic shock. * patients with documented fungal infection. * patients on mechanical ventilation. * patients hospitalized for covid-19 for more than 7 days.

- hypersensitivity to natural or recombinant interferon-ß - hypersensitivity to human albumin or mannitol - recent suicide attempt - decompensation of liver failure - age < 18 years - pregnant or nursing. - patients managed on an outpatient basis (i.e. not initially hospitalized). - parenteral ifn treatment. in periode b, addition of new exclusion criteria - patients with kidney transplant - immunocompromised patients - patients with severe systemic disease constantly threatening their vital prognosis (asa ≥ iv: e.g. severe arf, advanced cancer pathology, recent myocardial idm, severe valvular dysfunction, dependence on parenteral nutrition on central line, shock, sepsis, trauma, ...). - patients in septic shock. - patients with documented fungal infection. - patients on mechanical ventilation. - patients hospitalized for covid-19 for more than 7 days.

- hypersensitivity to natural or recombinant interferon-ß - hypersensitivity to human albumin or mannitol - recent suicide attempt - decompensation of liver failure - age < 18 years - pregnant or nursing. - patients managed on an outpatient basis (i.e. not initially hospitalized). - parenteral ifn treatment. in periode b, addition of new exclusion criteria - patients with kidney transplant - immunocompromised patients - patients with severe systemic disease constantly threatening their vital prognosis (asa ≥ iv: e.g. severe arf, advanced cancer pathology, recent myocardial idm, severe valvular dysfunction, dependence on parenteral nutrition on central line, shock, sepsis, trauma, ...). - patients in septic shock. - patients with documented fungal infection. - patients on mechanical ventilation. - patients hospitalized for covid-19 for more than 7 days.

- hypersensitivity to natural or recombinant interferon-ß - hypersensitivity to human albumin or mannitol - recent suicide attempt - decompensation of liver failure - age < 18 years - pregnant or nursing. - patients managed on an outpatient basis (i.e. not initially hospitalized). - parenteral ifn treatment.

- hypersensitivity to natural or recombinant interferon-ß - hypersensitivity to human albumin or mannitol - recent suicide attempt - decompensation of liver failure - age < 18 years - pregnant or nursing. - patients managed on an outpatient basis (i.e. not initially hospitalized). - parenteral ifn treatment.