inclusion criteria: * age \> 18 yrs * both genders * lab confirmed covid-19 infection by pcr or plasma positive of specific antibody against covid-19 * in hospital treatment ≥ 72 hours * admitted patients * severe disease (respiratory rate \>=30/min; or (b) rest spo2\<=90%; or (c) pao2/fio2\<=300 mmhg) or * critical phase (respiratory failure and needs mechanical ventilation; or shock occurs; or multiple organ failure and needs icu monitoring)

inclusion criteria: * age \> 18 yrs * both genders * lab confirmed covid-19 infection by pcr or plasma positive of specific antibody against covid-19 * in hospital treatment ≥ 72 hours * admitted patients * severe disease (respiratory rate \>=30/min; or (b) rest spo2\<=90%; or (c) pao2/fio2\<=300 mmhg) or * critical phase (respiratory failure and needs mechanical ventilation; or shock occurs; or multiple organ failure and needs icu monitoring)

inclusion criteria: - age > 18 yrs - both genders - lab confirmed covid-19 infection by pcr or plasma positive of specific antibody against covid-19 - in hospital treatment ≥ 72 hours - admitted patients - severe disease (respiratory rate >=30/min; or (b) rest spo2<=90%; or (c) pao2/fio2<=300 mmhg) or - critical phase (respiratory failure and needs mechanical ventilation; or shock occurs; or multiple organ failure and needs icu monitoring)

inclusion criteria: - age > 18 yrs - both genders - lab confirmed covid-19 infection by pcr or plasma positive of specific antibody against covid-19 - in hospital treatment ≥ 72 hours - admitted patients - severe disease (respiratory rate >=30/min; or (b) rest spo2<=90%; or (c) pao2/fio2<=300 mmhg) or - critical phase (respiratory failure and needs mechanical ventilation; or shock occurs; or multiple organ failure and needs icu monitoring)