Any case of CNS disorder that interferes with patient communication and educability Need to be admitted to the intensive care unit at the time of enrollment history of lung disease sPo2<94% (at room air) Participation in any other clinical trial of an experimental treatment for COVID-19 pregnant woman or man who his spouse is pregnant history of CHF Requiring mechanical ventilation at screening Evidence of multi-organ failure Recent of ACS no willingness for enrollment

Any case of CNS disorder that interferes with patient communication and educability Need to be admitted to the intensive care unit at the time of enrollment history of lung disease sPo2<94% (at room air) Participation in any other clinical trial of an experimental treatment for COVID-19 pregnant woman or man who his spouse is pregnant history of CHF Requiring mechanical ventilation at screening Evidence of multi-organ failure Recent of ACS no willingness for enrollment