Written informed consent prior to initiation of study. Age over 18 years. Laboratory-confirmed SARS-CoV-2 infection determined by PCR less than 72 hours before randomization. Illness of any duration, and at least one of the following:Radiographic infiltrates by imaging , OR Clinical assessment (evidence of rales/crackles on exam) AND SpO2 ≤ 94% on room air, OR Requiring mechanical ventilation and/or supplemental oxygen. Women of childbearing potential must agree to use at least one primary form of contraception for the duration of the study.

Written informed consent prior to initiation of study. Age over 18 years. Laboratory-confirmed SARS-CoV-2 infection determined by PCR less than 72 hours before randomization. Illness of any duration, and at least one of the following:Radiographic infiltrates by imaging , OR Clinical assessment (evidence of rales/crackles on exam) AND SpO2 ≤ 94% on room air, OR Requiring mechanical ventilation and/or supplemental oxygen. Women of childbearing potential must agree to use at least one primary form of contraception for the duration of the study.