Other systemic diseases (such as uncontrollable hypertension, uncontrolled diabetes, depression, elevated liver enzymes more than 3 times normal, cirrhosis, chronic kidney disease with GFR less than 30 cc / min) Allergy to melatonin Usage of anticoagulants such as warfarin or heparin with therapeutic doses Under mechanical ventilation

Other systemic diseases (such as uncontrollable hypertension, uncontrolled diabetes, depression, elevated liver enzymes more than 3 times normal, cirrhosis, chronic kidney disease with GFR less than 30 cc / min) Allergy to melatonin Usage of anticoagulants such as warfarin or heparin with therapeutic doses Under mechanical ventilation