Laboratory confirmation of Coronavirus disease-19 (COVID-19) virus by reverse transcription- polymerase chain reaction (RT-PCR) Moderate-severity disease (respiration rate more than 30 per minute, oxygen saturation more than 94%, or pulmonary infiltration less than 50% in both lungs) Age over 18 years Body mass index less than 40 kilogram per square meters No immunosuppressive diseases, including primary and secondary immunodeficiency, consumption of immunosuppressive drugs, organ transplants, chemotherapy or radiotherapy Patient willingness to participate in the study Existence of oral tolerance Non-pregnant and non-lactating women Not receiving antiviral drugs and other effective drugs in the treatment of COVID-19 in this clinical course No history of severe drug allergy and anaphylactic shock

Laboratory confirmation of Coronavirus disease-19 (COVID-19) virus by reverse transcription- polymerase chain reaction (RT-PCR) Moderate-severity disease (respiration rate more than 30 per minute, oxygen saturation more than 94%, or pulmonary infiltration less than 50% in both lungs) Age over 18 years Body mass index less than 40 kilogram per square meters No immunosuppressive diseases, including primary and secondary immunodeficiency, consumption of immunosuppressive drugs, organ transplants, chemotherapy or radiotherapy Patient willingness to participate in the study Existence of oral tolerance Non-pregnant and non-lactating women Not receiving antiviral drugs and other effective drugs in the treatment of COVID-19 in this clinical course No history of severe drug allergy and anaphylactic shock