ّThe level of specific IgG antibody against RBD protein in days 0 and 21 after booster injection based on GMI, GMT and seroconversion rate (increase at least 4 times in antibody titer) in Shahid Soleimani Clinical Trial Center (sample of 300 people). Cellular immune response to booster dose based on measurement of IL 4 and INFγ levels using ELISA method on days 0 and 21 after injection (subgroup of 90 people) Measurement of neutralizing antibody level by neutralization test method Virus (subgroup of 90 people)

ّThe level of specific IgG antibody against RBD protein in days 0 and 21 after booster injection based on GMI, GMT and seroconversion rate (increase at least 4 times in antibody titer) in Shahid Soleimani Clinical Trial Center (sample of 300 people). Cellular immune response to booster dose based on measurement of IL 4 and INFγ levels using ELISA method on days 0 and 21 after injection (subgroup of 90 people) Measurement of neutralizing antibody level by neutralization test method Virus (subgroup of 90 people)