Death of the patient Physician's diagnosis of not participating in the study History of thrombosis or current thrombosis Suppression of the known immune system Pregnancy and lactation Use of angiotensin converting inhibitors Severe renal, hepatic, respiratory and cardiovascular insufficiency Consumption of cytotoxic drugs Transfer to another hospital

Death of the patient Physician's diagnosis of not participating in the study History of thrombosis or current thrombosis Suppression of the known immune system Pregnancy and lactation Use of angiotensin converting inhibitors Severe renal, hepatic, respiratory and cardiovascular insufficiency Consumption of cytotoxic drugs Transfer to another hospital