Phase 1: Any immediate reaction after inoculation Phase 1: Percentage of local reactions (pain, redness, swelling, ....in injection site) Phase 1: Percentage of systemic events (fever, headache, chills, nausea, vomiting, diarrhoea, fatigue, muscle pain, arthralgia, ....) Phase 1: occurrence of any adverse event (serious or non-serious) Phase 2: Percentage of seroconversion occurrence Phase 2: Anti-Spike, Neutralizing Antibody, Anti-RBD titres (with GMT , GMI) Phase 2: Lymphocytes subset count and cytokines for determining cellular immunity

Phase 1: Any immediate reaction after inoculation Phase 1: Percentage of local reactions (pain, redness, swelling, ....in injection site) Phase 1: Percentage of systemic events (fever, headache, chills, nausea, vomiting, diarrhoea, fatigue, muscle pain, arthralgia, ....) Phase 1: occurrence of any adverse event (serious or non-serious) Phase 2: Percentage of seroconversion occurrence Phase 2: Anti-Spike, Neutralizing Antibody, Anti-RBD titres (with GMT , GMI) Phase 2: Lymphocytes subset count and cytokines for determining cellular immunity